Reference : Administration of erythopoietin and granulocyte colony-stimulating factor in donor/re...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/8929
Administration of erythopoietin and granulocyte colony-stimulating factor in donor/recipient pairs to collect peripheral blood progenitor cells (PBPC) and red blood cell units for use in the recipient after allogeneic PBPC transplantation.
English
Sautois, Brieuc mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Baudoux, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Thérapie cellulaire >]
Salmon, Jean mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
Michaux, S. [> > > >]
Schaaf-Lafontaine, Nicole mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie biologique et immuno hématologie >]
Pereira-Martins, Maguy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Paulus, Jean-Michel mailto [Université de Liège - ULg > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2001
Haematologica
Ferrata Storti Foundation
86
11
1209-18
Yes (verified by ORBi)
International
0390-6078
1592-8721
Pavia
Italy
[en] Adolescent ; Adult ; Blood Donors ; Cytapheresis/methods ; Erythrocyte Transfusion ; Erythropoietin, Recombinant/administration & dosage ; Feasibility Studies ; Female ; Graft Survival ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Hematopoietic Stem Cell Mobilization/methods ; Hematopoietic Stem Cell Transplantation ; Humans ; Leukapheresis ; Male ; Middle Aged ; Prospective Studies ; Transplantation, Homologous
[en] BACKGROUND AND OBJECTIVES: It may be useful to reduce the exposure of transplant recipients to homologous blood. This may be achieved by procuring donor-derived red blood cell (RBC) units, collecting more peripheral blood progenitor cells (PBPC) with a combination of granulocyte colony-stimulating factor (G-CSF) + recombinant human erythropoietin (rHuEpo) and by administering rHuEpo post-transplantation. DESIGN AND METHODS: Eight ABO-compatible donors were treated with rHuEpo and intravenous iron to collect 12 RBC units for use in their recipients. PBPC were collected after mobilization with rHuEpo and G-CSF in the same donors. The recipients received G-CSF and rHuEpo post-transplantation. A control group of 10 donor/recipient pairs received G-CSF alone for PBPC mobilization and after the transplantation. RESULTS: Eighty-six out of 91 planned RBC units were collected in the donors without significant decrease in hematocrit because of a 4-fold increase in RBC production despite functional iron deficiency. After 2 leukaphereses, the cumulative yields of NC and CFU-GM were lower in the study group while those of BFU-E, CFU-Mix and CD34+ cells were similar. However, erythroid recovery was significantly accelerated in the study group. INTERPRETATION AND CONCLUSIONS: Collection of 12 RBC units within 6 weeks is feasible with rHuEpo and intravenous iron; this strategy allows a dramatic reduction in recipient exposure to homologous blood; rHuEpo has no synergistic effect with G-CSF for mobilization of PBPC in normal donors and may even be deleterious; and rHuEpo in the recipient may enhance erythroid engraftment.
http://hdl.handle.net/2268/8929

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