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Vitamin D and type 2 diabetes mellitus: Where do we stand?

CAVALIER, Etienne; DELANAYE, Pierre; Souberbielle, Jean-Claude et al.

2011 • In Diabetes and Metabolism, 37 (4), p. 265-72

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/89018

DOI
10.1016/j.diabet.2011.01.001

PubMed
21345709

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Keywords :

vitamin D; type 2 diabetes mellitus; pathophysiology; review; vitamine D; diabète de type 2; physiopathologie; revue générale

Abstract :

[en] AIMS: In-vitro and observational studies have established a link between vitamin D deficiency and different type 2 diabetes outcomes (insulin resistance, insulin secretion, glucose intolerance). Although the number of randomized controlled trials vs placebo is small, vitamin D (VTD) has been shown to prevent increases in glucose concentration and insulin resistance, enhance insulin sensitivity and reduce systolic blood pressure in type 2 diabetic patients. METHODS: In this review, we have focused on the potential mechanisms that might explain the association between VTD and type 2 diabetes mellitus (T2DM). We have also evaluated the different epidemiological and observational studies on the topic, as well as the various interventional studies. RESULTS: Although the in vitro studies appear to be promising in explaining the link between VTD metabolism and T2DM, the results of in vivo studies are conflicting. This could be related to differences in their methodological approaches. CONCLUSION: Although more studies are needed to confirm the role of VTD in the treatment of T2DM, there is nevertheless enough evidence at this time to suggest a need to maintain 25-OH vitamin D levels in T2DM patients around 30ng/mL over the course of a year.

Disciplines :

Laboratory medicine & medical technology

Author, co-author :

CAVALIER, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Chimie médicale

DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Néphrologie

Souberbielle, Jean-Claude

RADERMECKER, Régis ; Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques

Language :

English

Title :

Vitamin D and type 2 diabetes mellitus: Where do we stand?

Publication date :

September 2011

Journal title :

Diabetes and Metabolism

ISSN :

1262-3636

eISSN :

1878-1780

Publisher :

Masson, Moulineaux Cedex 9, France

Volume :

37

Issue :

4

Pages :

265-72

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 April 2011

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Scopus citations^®

44

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without self-citations

39

OpenCitations

34

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