Reference : Brain energization in response to deep brain stimulation of subthalamic nuclei in Parkin...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Human health sciences : Neurology
http://hdl.handle.net/2268/88779
Brain energization in response to deep brain stimulation of subthalamic nuclei in Parkinson's disease.
English
Garraux, Gaëtan mailto [Université de Liège - ULg > Département des sciences cliniques > Neurologie >]
Bahri, Mohamed Ali mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron]
Degueldre, Christian mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.]
Salmon, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurochirurgie]
KASCHTEN, Bruno mailto [ > > ]
Apr-2011
Journal of Cerebral Blood Flow & Metabolism
Nature Publishing Group
Yes (verified by ORBi)
International
0271-678X
1559-7016
New York
NY
[en] parkinson's disease ; PET ; DBS ; neurosurgery
[en] Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment in a subgroup of medically refractory patients with Parkinson's disease (PD). Here, we compared resting-state (18)F-fluorodeoxyglucose (FDG) positron emission tomography images in the stimulator off (DBS_OFF) and on (DBS_ON) conditions in eight PD patients in an unmedicated state, on average 2 years after bilateral electrode implantation. Global standardized uptake value (SUV) significantly increased by approximately 11% in response to STN-DBS. To avoid any bias in the voxel-based analysis comparing DBS_ON and DBS_OFF conditions, individual scan intensity was scaled to a region where FDG-SUV did not differ significantly between conditions. The resulting FDG-SUV ratio (FDG-SUVR) was found to increase in many regions in response to STN-DBS including the target area of surgery, caudate nuclei, primary sensorimotor, and associative cortices. Contrary to previous studies, we could not find any regional decrease in FDG-SUVR. These findings were indirectly supported by comparing the extent of areas with depressed FDG-SUVR in DBS_OFF and DBS_ON relatively to 10 normal controls. Altogether, these novel results support the prediction that the effect of STN-DBS on brain activity in PD is unidirectional and consists in an increase in many subcortical and cortical regions.Journal of Cerebral Blood Flow & Metabolism advance online publication, 6 April 2011; doi:10.1038/jcbfm.2011.41.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Rahier
Researchers ; Professionals
http://hdl.handle.net/2268/88779
10.1038/jcbfm.2011.41
http://www.nature.com/jcbfm/journal/vaop/ncurrent/full/jcbfm201141a.html

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