No full text
Article (Scientific journals)
Effectors of Inflammation in Actinic Prurigo
Arrese, J. E.; Dominguez-Soto, L.; Hojyo-Tomoka, M. T. et al.
2001In Journal of the American Academy of Dermatology, 44 (6), p. 957-61
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] BACKGROUND: Actinic prurigo is a specific familial photodermatosis of uncertain pathogenesis. OBJECTIVE: Our purpose was to investigate the immunohistologic presentation of actinic prurigo to explore the involved pathomechanisms. METHODS: The present immunohistochemical study was performed on biopsy specimens from 20 Mexican patients presenting with a severe and perennial form of the disease. RESULTS: The dense inflammatory infiltrate was composed predominantly of helper T type 1 lymphocytes admixed with scattered B-cell lymphoid follicles and numerous dermal dendrocytes. Keratinocytes contained abundant tumor necrosis factor-alpha and calprotectin. CONCLUSION: In subjects genetically predisposed to actinic prurigo, ultraviolet light may trigger excessive tumor necrosis factor-alpha production by keratinocytes whose sustained release in turn exerts its proinflammatory activity and deleterious epidermal effects. Such a cascade of events is in line with the therapeutic benefit already reported when thalidomide is used to treat actinic prurigo.
Disciplines :
Dermatology
Author, co-author :
Arrese, J. E.
Dominguez-Soto, L.
Hojyo-Tomoka, M. T.
Vega-Memije, E.
Cortes-Franco, R.
Guevara, E.
Pierard, Gérald ;  Université de Liège - ULiège > Département des sciences cliniques > Dermatopathologie
Language :
English
Title :
Effectors of Inflammation in Actinic Prurigo
Publication date :
June 2001
Journal title :
Journal of the American Academy of Dermatology
ISSN :
0190-9622
eISSN :
1097-6787
Publisher :
Mosby, United States - New York
Volume :
44
Issue :
6
Pages :
957-61
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 31 March 2011

Statistics


Number of views
52 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
38
Scopus citations®
without self-citations
23
OpenCitations
 
31

Bibliography


Similar publications



Contact ORBi