ORBi: Strekalova Tatyana - Update in the methodology of the chronic stress paradigm: internal control matters

Reference : Update in the methodology of the chronic stress paradigm: internal control matters


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Anatomy (cytology, histology, embryology...) & physiology
	To cite this reference:	http://hdl.handle.net/2268/87937

Title :	Update in the methodology of the chronic stress paradigm: internal control matters
Language :	English
Author, co-author :	Strekalova, Tatyana [Universiteit Maastricht > Department of Neuroscience > > > >]
	Couch [University of Oxford > Department of Pharmacology > > >]
	Kholod, Natalia [Universiteit Maastricht > Department of Neuroscience > > >]
	Boyks, Marco [Universiteit Maastricht > Department of Neuroscience > > > >]
	Malin, Dmitry [Northwestern University > Feinberg School of Medicine > Lurie Cancer Center > > >]
	Leprince, Pierre [Université de Liège - ULg > > GIGA - Neurosciences >]
	Steinbusch, Harry [Universiteit Maastricht > Department of Neuroscience > > >]
Publication date :	27-Apr-2011
Journal title :	Behavioral and Brain Functions : BBF
Volume :	7
Pages :	9
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
e-ISSN :	1744-9081
Keywords :	[en] animal model of depression ; chronic stress ; sucrose test ; anhedonia ; antidepressant treatment ; gene expression profiling
Abstract :	[en] To date, the reliability of induction of a depressive-like state using chronic stress models is confronted by many methodological limitations. We believe that the modifications to the stress paradigm in mice proposed herein allow some of these limitations to be overcome. Here, we discuss a variant of the standard stress paradigm, which results in anhedonia. This anhedonic state was defined by a decrease in sucrose preference that was not exhibited by all animals. As such, we propose the use of non-anhedonic, stressed mice as an internal control in experimental mouse models of depression. The application of an internal control for the effects of stress, along with optimized behavioural testing, can enable the analysis of biological correlates of stressinduced anhedonia versus the consequences of stress alone in a chronic-stress depression model. This is illustrated, for instance, by distinct physiological and molecular profiles in anhedonic and non-anhedonic groups subjected to stress. These results argue for the use of a subgroup of individuals who are negative for the induction of a depressive phenotype during experimental paradigms of depression as an internal control, for more refined modeling of this disorder in animals
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/87937
Other URL :	http://www.behavioralandbrainfunctions.com/content/7/1/9

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