No full text
Article (Scientific journals)
The basement membrane proteins laminin and type IV collagen in isolated villi in pre-eclampsia
Risteli, J.; Foidart, Jean-Michel; Risteli, L. et al.
1984In Placenta, 5 (6), p. 541-50
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] The distribution and concentrations of the basement membrane proteins laminin and type IV collagen were studied in isolated placental villi in normal pregnancy and in pre-eclampsia. In both cases these proteins could be localized by immunofluorescence in the trophoblast and capillary basement membranes, and occasionally also in the matrix surrounding the capillaries. The basement membrane proteins were quantified by solubilizing the villi with proteolytic enzymes and by subsequently measuring the concentrations of two resistant domains of these proteins (7-S collagen and the fragment PI, representing type IV collagen and laminin, respectively) with specific radioimmunoassays. The ratio type IV collagen:laminin was significantly higher in pre-eclamptic samples than in the controls, most probably reflecting a decrease in laminin concentration in the villi in pre-eclampsia. Such a change in the chemical composition of placental basement membranes could weaken the attachment of trophoblast cells to the underlying basement membrane and also modify the permeability and exchange properties of the villi.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Risteli, J.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique
Risteli, L.
Boniver, Jacques ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Goffinet, G.
Language :
English
Title :
The basement membrane proteins laminin and type IV collagen in isolated villi in pre-eclampsia
Publication date :
1984
Journal title :
Placenta
ISSN :
0143-4004
eISSN :
1532-3102
Publisher :
W.B. Saunders, London, United Kingdom
Volume :
5
Issue :
6
Pages :
541-50
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 March 2011

Statistics


Number of views
28 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
19
Scopus citations®
without self-citations
18
OpenCitations
 
18

Bibliography


Similar publications



Contact ORBi