Article (Scientific journals)
Gamma-probe-directed lymphatic mapping and sentinel lymphadenectomy in primary cutaneous melanoma.
Belhocine, T.; Pierard, Gérald; Gielen, Jean-Louis et al.
2002In Dermatology, 204 (4), p. 355-61
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Keywords :
Female; Humans; Lymph Node Excision; Lymph Nodes/pathology/radionuclide imaging; Lymphatic Metastasis; Male; Melanoma/radionuclide imaging/secondary; Middle Aged; Prognosis; Sensitivity and Specificity; Sentinel Lymph Node Biopsy; Skin Neoplasms/pathology; Survival Analysis
Abstract :
[en] BACKGROUND: Radiotracer and blue-dye lymphatic mapping is a recommended combined method to guide sentinel lymphadenectomy and full regional lymph node dissection in selected patients with cutaneous melanoma. OBJECTIVE: To evaluate the diagnostic accuracy and the prognostic value of gamma-probe-directed lymphatic mapping in cutaneous melanomas. METHODS: Sixty-five stage I and II melanoma patients underwent gamma-probe-directed lymphatic mapping. Sentinel lymph nodes were studied by both conventional and immunohistochemical stainings. The median follow-up was 11 months. RESULTS: Sensitivities of preoperative and intraoperative sentinel lymph node detection were 100 and 98%, respectively. Only 1 failure of detection and 1 missed same-basin metastasis were experienced in the axillary and cervical areas, respectively. Eleven patients (16.9%) had sentinel node metastases leading to adjuvant therapy. CONCLUSION: Gamma-probe-directed lymphatic mapping is useful for staging melanoma. However, in the expectation of a more specific identification of the sentinel lymph node, the standard protocol remains recommended for exploring the axillary and cervical areas. The histological examination supported in some cases by immunohistochemistry remains mandatory in all cases.
Disciplines :
Dermatology
Author, co-author :
Belhocine, T.;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Gielen, Jean-Louis ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie maxillo-faciale et plastique
Daenen, Frédéric ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
De Barsy, C.
Arrese Estrada, Jorge ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Lahaye, Thierry ;  Centre Hospitalier Universitaire de Liège - CHU > Chirurgie générale
Rigo, Pierre ;  Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
Language :
English
Title :
Gamma-probe-directed lymphatic mapping and sentinel lymphadenectomy in primary cutaneous melanoma.
Publication date :
2002
Journal title :
Dermatology
ISSN :
1018-8665
eISSN :
1421-9832
Publisher :
S. Karger, Basel, Switzerland
Volume :
204
Issue :
4
Pages :
355-61
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 March 2011

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