Article (Scientific journals)
The therapeutic potential of TNF-alpha antagonists for skin psoriasis comorbidities.
Pierard, Gérald; Pierard, Claudine; Szepetiuk, Grégory et al.
2010In Expert Opinion on Biological Therapy, 10 (8), p. 1197-208
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Abstract :
[en] IMPORTANCE OF THE FIELD: Alopecia, psoriatic arthritis, the metabolic syndrome, inflammatory bowel diseases and cardiovascular diseases may occur as skin psoriatic comorbidities. TNF-alpha antagonists are used to treat psoriasis. Adalimumab is one of the recognized active agents for this indication. AREAS COVERED IN THIS REVIEW: The current peer-reviewed publications and presentation of original findings. WHAT THE READER WILL GAIN: Adalimumab is active on recalcitrant psoriasis and some of its comorbidities, particularly arthropathies and Crohn's disease. However, the progression of the radiological alterations is limited with regression of the bony erosions. Psoriatic enthesopathy also regresses. Mortality associated with psoriasis arthropathy is on the decline. Crohn's disease, the most frequent inflammatory bowel comorbidity of psoriasis, is responsive to adalimumab. The effect of adalimumab on the metabolic syndrome and cardiovascular involvement is more erratic. The spectacular effects of adalimumab may be associated with some adverse effects. In particular, despite a marked reduction in the psoriasis area-and-severity index (PASI) score some new acute lesions of cutaneous psoriasis may develop corresponding to paradoxical psoriasis. Other potential adverse effects include infections, granulomas, rapid growth of cancers and occurrence of lymphomas. TAKE HOME MESSAGE: Adalimumab frequently controls moderate-to-severe forms of cutaneous psoriasis and some of its comorbidities.
Disciplines :
Dermatology
Author, co-author :
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Claudine ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Szepetiuk, Grégory ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Paquet, Philippe ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Quatresooz, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
The therapeutic potential of TNF-alpha antagonists for skin psoriasis comorbidities.
Publication date :
2010
Journal title :
Expert Opinion on Biological Therapy
ISSN :
1471-2598
eISSN :
1744-7682
Publisher :
Taylor & Francis, United Kingdom
Volume :
10
Issue :
8
Pages :
1197-208
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 March 2011

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