ORBi: Mottet Marie - The role of the thymus in integrated evolution of the recombinase-dependent adaptive immune response and the neuroendocrine system

Reference : The role of the thymus in integrated evolution of the recombinase-dependent adaptive imm...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Multidisciplinary, general & others Human health sciences : Immunology & infectious disease Human health sciences : Endocrinology, metabolism & nutrition
	To cite this reference:	http://hdl.handle.net/2268/87539

Title :	The role of the thymus in integrated evolution of the recombinase-dependent adaptive immune response and the neuroendocrine system
Language :	English
Author, co-author :	Mottet, Marie [Université de Liège - ULg > > Centre d'immunologie >]
	Goffinet, Lindsay [Université de Liège - ULg > > Centre d'immunologie >]
	Beckers, Alisson [Université de Liège - ULg > Centre d'Immunologie > > >]
	Bodart, Gwennaëlle [Université de Liège - ULg > > > Doct. sc. bioméd. & pharma. (Bologne)]
	Morrhaye, Gabriel [Université de Liège - ULg > Centre d'Immunologie > > >]
	Kermani, Hamid [Université de Liège - ULg > Centre d'Immunologie > > >]
	RENARD-CHARLET, Jeanne de Chantal [Centre Hospitalier Universitaire de Liège - CHU > > Endocrinologie clinique >]
	Martens, Henri [Université de Liège - ULg > > Centre d'immunologie >]
	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie >]
Publication date :	2011
Journal title :	Neuroimmunomodulation
Publisher :	S. Karger
Volume :	18
Special issue title :	Neuroendocrinology of the thymus
Pages :	314-319
Audience :	International
ISSN :	1021-7401
e-ISSN :	1423-0216
City :	Basel
Country :	Switzerland
Keywords :	[en] Thymus ; Self-tolerance ; Neuroendocrine self-antigens ; Autoimmunity ; Evolution
Abstract :	[en] Before being able to react against infectious non-self antigens, the immune system has to be educated in recognition and tolerance of neuroendocrine self-proteins. This sophisticated educational process takes place only in the thymus. The development of an autoimmune response directed to neuroendocrine glands has been shown to result from a thymus dysfunction in programming immunological self-tolerance to neuroendocrine-related antigens. This thymus dysfunction leads to a breakdown of immune homeostasis with an enrichment of ‘forbidden’ self-reactive T cells and a deficiency in self-antigen specific natural regulatory T cells (nTreg) in the peripheral T-lymphocyte repertoire. A large number of neuroendocrine self-antigens are expressed by the thymic epithelium, under the control of the autoimmune regulator (AIRE) gene/protein in the medulla. Based on the close homology and cross-tolerance between thymic type 1 diabetes-related self-antigens and peripheral antigens targeted in β cells by autoimmunity, a novel type of vaccination is currently developed for prevention and cure of type 1 diabetes. If this approach were found to be effective in reprogramming immunological tolerance that is absent or broken in this disease, it could pave the way for the design of negative/tolerogenic self-vaccines against other endocrine and organ-specific autoimmune disorders.
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fonds Léon Fredericq ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Union Européenne = European Union - UE = EU ; European Association for the Study of Diabetes (EASD) ; Juvenile Diabetes Research Federation (JDRF, New York)
Name of the research project :	Tolediab - Eurothymaide
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/87539

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Restricted access	Mottet_NIM_2011.pdf		Publisher postprint	313.97 kB	Request copy

All documents in ORBi are protected by a user license.

Dspace v1.5