Reference : Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted wi...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Human health sciences : Geriatrics
http://hdl.handle.net/2268/87495
Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture
English
Vo, Thi Kim Duy [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
de Saint-Hubert, Marie [Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne > > >]
Morrhaye, Gabriel [Université de Liège - ULg > Centre d'Immunologie > > >]
Godard, Patrice [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie >]
Martens, Henri mailto [Université de Liège - ULg > > Centre d'immunologie >]
Debacq-Chainiaux, Florence [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
Swine, Christian [Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne > > >]
Toussaint, Olivier [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
2011
Mechanisms of Ageing & Development
Elsevier Science Ireland
132
131-139
Yes (verified by ORBi)
International
0047-6374
Limerick
Ireland
[en] Ageing ; Gene expression ; Heart failure ; Inflammation ; Immunosenescence ; Oxidative stress
[en] The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress
response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart
failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart
failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress weremore
abundant. Those associated with T-cell functions were less abundant. The results were compared to two
other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to
healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious
diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of
CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy
young subjects, was further affected in acute phase of the three geriatric diseases considered. The
transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in
all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In
conclusion, this work provides critical targets for therapeutic research on geriatric heart failure,
infectious diseases and hip fracture.
Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
SENEGENE
Researchers ; Professionals
http://hdl.handle.net/2268/87495
10.1016/j.mad.2011.02.002

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