Article (Scientific journals)
Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture
Vo, Thi Kim Duy; de Saint-Hubert, Marie; Morrhaye, Gabriel et al.
2011In Mechanisms of Ageing and Development, 132, p. 131-139
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Keywords :
Ageing; Gene expression; Heart failure; Inflammation; Immunosenescence; Oxidative stress
Abstract :
[en] The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress weremore abundant. Those associated with T-cell functions were less abundant. The results were compared to two other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy young subjects, was further affected in acute phase of the three geriatric diseases considered. The transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In conclusion, this work provides critical targets for therapeutic research on geriatric heart failure, infectious diseases and hip fracture.
Disciplines :
Geriatrics
Immunology & infectious disease
Author, co-author :
Vo, Thi Kim Duy;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
de Saint-Hubert, Marie;  Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne
Morrhaye, Gabriel;  Université de Liège - ULiège > Centre d'Immunologie
Godard, Patrice;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Martens, Henri ;  Université de Liège - ULiège > Centre d'immunologie
Debacq-Chainiaux, Florence;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
Swine, Christian;  Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne
Toussaint, Olivier;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
Language :
English
Title :
Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture
Publication date :
2011
Journal title :
Mechanisms of Ageing and Development
ISSN :
0047-6374
Publisher :
Elsevier Science Ireland, Limerick, Ireland
Volume :
132
Pages :
131-139
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
SENEGENE
Funders :
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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