ORBi: Vo Thi Kim Duy - Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture

Reference : Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted wi...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease Human health sciences : Geriatrics
	To cite this reference:	http://hdl.handle.net/2268/87495

Title :	Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison to hospitalized geriatric patients with infectious diseases or hip fracture
Language :	English
Author, co-author :	Vo, Thi Kim Duy [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
	de Saint-Hubert, Marie [Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne > > >]
	Morrhaye, Gabriel [Université de Liège - ULg > Centre d'Immunologie > > >]
	Godard, Patrice [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie >]
	Martens, Henri [Université de Liège - ULg > > Centre d'immunologie >]
	Debacq-Chainiaux, Florence [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
	Swine, Christian [Université Catholique de Louvain - UCL > Gériatrie-Mont Godinne > > >]
	Toussaint, Olivier [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
Publication date :	2011
Journal title :	Mechanisms of Ageing & Development
Publisher :	Elsevier Science Ireland
Volume :	132
Pages :	131-139
Audience :	International
ISSN :	0047-6374
City :	Limerick
Country :	Ireland
Keywords :	[en] Ageing ; Gene expression ; Heart failure ; Inflammation ; Immunosenescence ; Oxidative stress
Abstract :	[en] The abundance of a preselection of transcripts involved in inflammation, immunosenescence and stress response was compared between PBMC of healthy aged donors and aged patients in acute phase of heart failure and at recovery. This study identified 22 transcripts differentially abundant in acute phase of heart failure versus healthy aged subjects. Transcripts involved in inflammation and oxidative stress weremore abundant. Those associated with T-cell functions were less abundant. The results were compared to two other major acute geriatric issues: infectious diseases and hip fracture. In acute phase, compared to healthy aged subjects, the abundance of 15/22 transcripts was also altered in both geriatric infectious diseases and hip fracture. Many variations had not vanished at the recovery phase. The abundance of CD28, CD69, LCK, HMOX1, TNFRSF1A transcripts, known to be altered in healthy aged versus healthy young subjects, was further affected in acute phase of the three geriatric diseases considered. The transcript levels of BCL2, CASP8, CCL5, DDIT3, EGR3, IL10RB, IL1R2, SERPINB2 and TIMP1 were affected in all three pathological conditions compared to healthy aged, but not versus healthy young subjects. In conclusion, this work provides critical targets for therapeutic research on geriatric heart failure, infectious diseases and hip fracture.
Funders :	Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Name of the research project :	SENEGENE
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/87495
DOI :	10.1016/j.mad.2011.02.002

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