Reference : Investigation of human JC and BK polyomaviruses in breast carcinomas
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/87478
Investigation of human JC and BK polyomaviruses in breast carcinomas
English
Hachana, Mohamed Ridha [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
Amara, Khaled [ > > ]
Ziadi, Sonia [ > > ]
Ben Gacem, Riadh [ > > ]
Korbi, Sadok [ > > ]
Trimeche, Mounir [ > > ]
2011
Breast Cancer Research and Treatment
Kluwer Academic Publishers
Yes (verified by ORBi)
International
0167-6806
Dordrecht
The Netherlands
[en] Breast cancer ; Polyomaviruses ; BK virus ; JC virus ; Tunisia
[en] We have previously showed the presence of the simian virus 40 (SV40) and the mouse mammary tumor virus (MMTV)-like in a significant proportions of Tunisian breast carcinomas. However, to date there are no published studies concerning evaluation of the possible implication of the human polyomaviruses JC (JCV) and BK (BKV) in breast carcinomas. The presence of JCV and BKV DNA was investigated by PCR in a 123 primary breast carcinomas and matched adjacent non-tumor breast tissues. The results were correlated to clinicopathological and virological parameters. JCV T-antigen DNA was detected in 23% of breast carcinoma cases; however, all cases were negative for BKV. JCV T antigen PCR products were further confirmed as authentic JCV genome by direct sequencing. JCV was found in invasive ductal carcinomas (28/112 cases) but not in invasive lobular carcinomas (0/5) or medullary carcinomas (0/6). JCV DNA presence correlates inversely with the expression of estrogen (P = 0.022) and progesterone (P = 0.008) receptors. JCV DNA presence correlates also with "triple negative" phenotype (P = 0.021). With regard to virological data, a trend toward an inverse correlation was noted between the presence of JCV and SV40 (P = 0.06). Moreover, significant correlation was found between multiple viral infection (JCV, and/or SV40, and/or MMTV-like in the same tumor) and "triple negative" phenotype (P = 0.001) and also with p53 accumulation (P = 0.028). To the best of our knowledge, this is the first study demonstrating the presence of JCV in a subset of breast carcinomas. Also our results suggest that "triple negative" breast carcinomas are viral-related tumors.
Researchers ; Professionals
http://hdl.handle.net/2268/87478
10.1007/s10549-011-1876-5

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
10.1007_s10549-011-1876-5.pdfPublisher postprint566.14 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.