Article (Scientific journals)
Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate
Bruyère, Olivier; Roux, C.; Detilleux, Johann et al.
2007In Journal of Clinical Endocrinology and Metabolism, 92 (8), p. 3076-3081
Peer Reviewed verified by ORBi
 

Files


Full Text
2341.pdf
Publisher postprint (112.13 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] Objective: Our objective was to analyze the relationship between bone mineral density (BMD) changes and fracture incidence during 3-yr treatment with strontium ranelate. Patients: Women from the strontium ranelate arm of the Spinal Osteoporosis Therapeutic Intervention study and the TReatment Of Peripheral OSteoporosis study were evaluated. Outcome Measures: The outcome measures included BMD at the lumbar spine, femoral neck, and total proximal femur assessed at baseline and after a follow-up of 1 and 3 yr; semiquantitative visual assessment of vertebral fractures; and nonvertebral fractures based on written documentation. Results: After 3 yr of strontium ranelate treatment, each percentage point increase in femoral neck and total proximal femur BMD was associated with a 3%(95% adjusted confidence interval, 1-5%) and2% (1-4%) reduction in risk of a new vertebral fracture, respectively. The 3- yr changes in femoral neck and total proximal femur BMD explained 76% and 74%, respectively, of the reduction in vertebral fractures observed during the treatment. Three-year changes in spine BMD were not statistically associated with the incidence of new vertebral fracture (P = 0.10). No significant associations were found between 3- yr changes in BMD and incidence of new nonvertebral fractures, but a trend was found for femoral neck BMD (P = 0.09) and for total proximal femur BMD (P = 0.07). An increase in femoral neck BMD after 1 yr was significantly associated with the reduction in incidence of new vertebral fractures observed after 3 yr (P = 0.04). Conclusion: During 3-yr strontium ranelate treatment, an increase in femoral neck BMD was associated with a proportional reduction in vertebral fracture incidence.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
Roux, C.
Detilleux, Johann ;  Université de Liège - ULiège > Département de productions animales > Génétique quantitative
Slosman, D. O.
Spector, T. D.
Fardellone, P.
Brixen, K.
Devogelaer, J. P.
Diaz-Curiel, M.
Albanese, C.
Kaufman, J. M.
Pors-Nielsen, S.
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie et santé publique
More authors (3 more) Less
Language :
English
Title :
Relationship between bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate
Publication date :
August 2007
Journal title :
Journal of Clinical Endocrinology and Metabolism
ISSN :
0021-972X
eISSN :
1945-7197
Publisher :
Endocrine Soc, Chevy Chase, United States - Maryland
Volume :
92
Issue :
8
Pages :
3076-3081
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 March 2009

Statistics


Number of views
111 (22 by ULiège)
Number of downloads
218 (8 by ULiège)

Scopus citations®
 
127
Scopus citations®
without self-citations
95
OpenCitations
 
103

Bibliography


Similar publications



Contact ORBi