Reference : Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in...
Scientific journals : Article
Human health sciences : Oncology
http://hdl.handle.net/2268/87468
Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Tunisia
English
Trimeche, Mounir [ > > ]
Ksiâa, Feryel [ > > ]
Ziadi, Sonia [ > > ]
Mestiri, Sarra [ > > ]
Hachana, Mohamed Ridha [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
Ben Gacem, Riadh [ > > ]
Sriha, Badreddine [ > > ]
Korbi, Sadok [ > > ]
Sep-2009
European Journal of Gastroenterology & Hepatology
Lippincott Williams & Wilkins
21
9
1001-1007
Yes (verified by ORBi)
International
0954-691X
London
United Kingdom
[en] Epstein–Barr virus ; gastric carcinoma ; immunohistochemistry ; in-situ hybridization ; polymerase chain reaction ; Tunisia
[en] Objective Epstein–Barr virus (EBV) has been linked to
gastric carcinoma (GC) with worldwide geographical
variations of prevalence ranging from 1 to 18% of cases.
Investigations carried out in north Africa have shown that
some EBV-associated types of cancers are common in this
area. This study was taken to determine the prevalence of
EBV-associated GC in Tunisia.
Methods Ninety-six nonselected GC cases (male/female
ratio 1.7/1, mean age 60.9 years, range: 20–88 years) were
evaluated for the presence of EBV by polymerase chain
reaction as well as by in-situ hybridization for EBVencoded
small RNAs (EBERs) and immunohistochemistry
for LMP-1 and EBNA-2 expression.
Results EBV was detected by polymerase chain reaction
in 36% of cases, whereas EBERs were detected in the
tumor cells in only four cases (4.1%).
Immunohistochemistry for LMP-1 and EBNA-2 was
negative in all cases. The mean age for patients harboring
EBERs-positive GC was 55.7 years (range: 52–59 years).
All EBERs-positive GC cases were males of advanced
clinical stage (pT3–pT4). According to Lauren’s
classification, two cases were of diffuse histological type
and two cases were of intestinal type. In three cases, the
tumors have a proximal location and in the remaining case
the tumor arises in the antrum. All EBV strains detected
from EBV-associated GC were exclusively of type A and D,
prototype F, and XhoI-maintained variant.
Conclusion We conclude that the prevalence of
EBV-associated GC in Tunisia is low (4.1%), suggesting
that this virus is not an important etiological factor in GC
arising in north African populations. The clinicopathological
profile of EBV-associated GC in Tunisia did not differ
markedly from that found elsewhere.
CHU FARHAT HACHED de Soussse
MINISTERE DE L'ENSEIGNEMENT SUPERIEUR ET DE LA RECHERCHE SCIENTIFIQUE EN TUNISIE
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/87468

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
Prevalence and characteristics of Epstein–Barr virus in gastric carcinomas.pdfPublisher postprint230.82 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.