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| Reference : Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Tu... |
| Scientific journals : Article | |||
| Human health sciences : Oncology | |||
| http://hdl.handle.net/2268/87468 | |||
| Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Tunisia | |
| English | |
| Trimeche, Mounir [ > > ] | |
| Ksiâa, Feryel [ > > ] | |
| Ziadi, Sonia [ > > ] | |
| Mestiri, Sarra [ > > ] | |
Hachana, Mohamed Ridha  [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >] | |
| Ben Gacem, Riadh [ > > ] | |
| Sriha, Badreddine [ > > ] | |
| Korbi, Sadok [ > > ] | |
| Sep-2009 | |
| European Journal of Gastroenterology & Hepatology | |
| Lippincott Williams & Wilkins | |
| 21 | |
| 9 | |
| 1001-1007 | |
| Yes (verified by ORBi) | |
| International | |
| 0954-691X | |
| London | |
| United Kingdom | |
| [en] Epstein–Barr virus ; gastric carcinoma ; immunohistochemistry ; in-situ hybridization ; polymerase chain reaction ; Tunisia | |
| [en] Objective Epstein–Barr virus (EBV) has been linked to
gastric carcinoma (GC) with worldwide geographical variations of prevalence ranging from 1 to 18% of cases. Investigations carried out in north Africa have shown that some EBV-associated types of cancers are common in this area. This study was taken to determine the prevalence of EBV-associated GC in Tunisia. Methods Ninety-six nonselected GC cases (male/female ratio 1.7/1, mean age 60.9 years, range: 20–88 years) were evaluated for the presence of EBV by polymerase chain reaction as well as by in-situ hybridization for EBVencoded small RNAs (EBERs) and immunohistochemistry for LMP-1 and EBNA-2 expression. Results EBV was detected by polymerase chain reaction in 36% of cases, whereas EBERs were detected in the tumor cells in only four cases (4.1%). Immunohistochemistry for LMP-1 and EBNA-2 was negative in all cases. The mean age for patients harboring EBERs-positive GC was 55.7 years (range: 52–59 years). All EBERs-positive GC cases were males of advanced clinical stage (pT3–pT4). According to Lauren’s classification, two cases were of diffuse histological type and two cases were of intestinal type. In three cases, the tumors have a proximal location and in the remaining case the tumor arises in the antrum. All EBV strains detected from EBV-associated GC were exclusively of type A and D, prototype F, and XhoI-maintained variant. Conclusion We conclude that the prevalence of EBV-associated GC in Tunisia is low (4.1%), suggesting that this virus is not an important etiological factor in GC arising in north African populations. The clinicopathological profile of EBV-associated GC in Tunisia did not differ markedly from that found elsewhere. | |
| CHU FARHAT HACHED de Soussse | |
| MINISTERE DE L'ENSEIGNEMENT SUPERIEUR ET DE LA RECHERCHE SCIENTIFIQUE EN TUNISIE | |
| Researchers ; Professionals ; Students | |
| http://hdl.handle.net/2268/87468 |
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