ORBi: Vo Thi Kim Duy - Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls

Reference : Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease Human health sciences : Geriatrics
	To cite this reference:	http://hdl.handle.net/2268/87380

Title :	Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls
Language :	English
Author, co-author :	Vo, Thi Kim Duy [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > > Unité de recherche de biologie cellulaire > >]
	Godard, Patrice [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > > Unité de recherche de biologie cellulaire > >]
	de Saint-Hubert, Marie [Université Catholique de Louvain - UCL > Gériatrie Mont-Godinne > > >]
	Morrhaye, Gabriel [Université de Liège - ULg > Centre d'Immunologie > > >]
	Debacq-Chainiaux, Florence [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
	Swine, Christian [Université Catholique de Louvain - UCL > Gériatrie - Mont Godinne > > >]
	Geenen, Vincent [Université de Liège - ULg > > Centre d'immunologie >]
	Martens, Henri [Université de Liège - ULg > > Centre d'immunologie >]
	Toussaint, Olivier [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
Publication date :	2011
Journal title :	Experimental Gerontology
Publisher :	Elsevier Science
Volume :	46
Pages :	257-264
Audience :	International
ISSN :	0531-5565
City :	Tarrytown
Country :	NY
Keywords :	[en] Ageing ; Hip fracture ; PBMC ; Gene expression ; Inflammation ; Immunosenescence ; Oxidative stress
Abstract :	[en] The abundance of a selection of transcript species involved in in!ammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2–4 after hospitalization) or convalescence phase (days 7–10) and 28 healthy aged controls. Twenty-nine differentially abundant transcripts were identi"ed in acute phase versus healthy ageing. Twelve of these transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously identi"ed as differentially abundant in PBMC of healthy aged versus healthy young controls, with further alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and infectious diseases. The next question is whether these alterations are common to other geriatric diseases and/or preexist before the clinical onset of the diseases.
Funders :	Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Name of the research project :	SENEGENE
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/87380
DOI :	10.1016/j.exger.2010.10.012

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