Article (Scientific journals)
Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls
Vo, Thi Kim Duy; Godard, Patrice; de Saint-Hubert, Marie et al.
2011In Experimental Gerontology, 46, p. 257-264
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Keywords :
Ageing; Hip fracture; PBMC; Gene expression; Inflammation; Immunosenescence; Oxidative stress
Abstract :
[en] The abundance of a selection of transcript species involved in in!ammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2–4 after hospitalization) or convalescence phase (days 7–10) and 28 healthy aged controls. Twenty-nine differentially abundant transcripts were identi"ed in acute phase versus healthy ageing. Twelve of these transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously identi"ed as differentially abundant in PBMC of healthy aged versus healthy young controls, with further alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and infectious diseases. The next question is whether these alterations are common to other geriatric diseases and/or preexist before the clinical onset of the diseases.
Disciplines :
Geriatrics
Immunology & infectious disease
Author, co-author :
Vo, Thi Kim Duy;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
Godard, Patrice;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
de Saint-Hubert, Marie;  Université Catholique de Louvain - UCL > Gériatrie Mont-Godinne
Morrhaye, Gabriel;  Université de Liège - ULiège > Centre d'Immunologie
Debacq-Chainiaux, Florence;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
Swine, Christian;  Université Catholique de Louvain - UCL > Gériatrie - Mont Godinne
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Martens, Henri ;  Université de Liège - ULiège > Centre d'immunologie
Toussaint, Olivier;  Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire
Language :
English
Title :
Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls
Publication date :
2011
Journal title :
Experimental Gerontology
ISSN :
0531-5565
eISSN :
1873-6815
Publisher :
Elsevier Science, Tarrytown, United States - New York
Volume :
46
Pages :
257-264
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
SENEGENE
Funders :
DGTRE - Région wallonne. Direction générale des Technologies, de la Recherche et de l'Énergie [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
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