Reference : Differentially abundant transcripts in PBMC of hospitalized geriatric patients with h...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
Human health sciences : Geriatrics
http://hdl.handle.net/2268/87380
Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls
English
Vo, Thi Kim Duy [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > > Unité de recherche de biologie cellulaire > >]
Godard, Patrice [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > > Unité de recherche de biologie cellulaire > >]
de Saint-Hubert, Marie [Université Catholique de Louvain - UCL > Gériatrie Mont-Godinne > > >]
Morrhaye, Gabriel [Université de Liège - ULg > Centre d'Immunologie > > >]
Debacq-Chainiaux, Florence [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
Swine, Christian [Université Catholique de Louvain - UCL > Gériatrie - Mont Godinne > > >]
Geenen, Vincent mailto [Université de Liège - ULg > > Centre d'immunologie >]
Martens, Henri mailto [Université de Liège - ULg > > Centre d'immunologie >]
Toussaint, Olivier [Facultés Universitaires Notre-Dame de la Paix - Namur - FUNDP > Unité de recherche de biologie cellulaire > > >]
2011
Experimental Gerontology
Elsevier Science
46
257-264
Yes (verified by ORBi)
International
0531-5565
Tarrytown
NY
[en] Ageing ; Hip fracture ; PBMC ; Gene expression ; Inflammation ; Immunosenescence ; Oxidative stress
[en] The abundance of a selection of transcript species involved in in!ammation, immunosenescence and stress
response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2–4
after hospitalization) or convalescence phase (days 7–10) and 28 healthy aged controls. Twenty-nine
differentially abundant transcripts were identi"ed in acute phase versus healthy ageing. Twelve of these
transcripts remained differentially abundant in convalescence phase, and 22 were similarly differentially
abundant in acute phase of geriatric infectious diseases. Seven of these 22 transcripts were previously
identi"ed as differentially abundant in PBMC of healthy aged versus healthy young controls, with further
alteration for CD28, CD69, LCK, CTSD, HMOX1, and TNFRSF1A in acute phase after geriatric hip fracture and
infectious diseases. The next question is whether these alterations are common to other geriatric diseases
and/or preexist before the clinical onset of the diseases.
Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE ; Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
SENEGENE
Researchers ; Professionals
http://hdl.handle.net/2268/87380
10.1016/j.exger.2010.10.012

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