Reference : Extensive Genome-Wide Linkage Disequilibrium in Cattle
Scientific journals : Article
Life sciences : Animal production & animal husbandry
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/8736
Extensive Genome-Wide Linkage Disequilibrium in Cattle
English
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
Arranz, J. J. [> > > >]
Berzi, Paulette mailto [Université de Liège - ULg > Services administratifs généraux > R&D : Gestion stratégique >]
Cambisano, Nadine mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Grisart, B. [> > > >]
Karim, Latifa mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Marcq, Fabienne mailto [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Département clinique des animaux de compagnie et des équidés >]
Moreau, L. [> > > >]
Mni, Myriam mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Nezer, Carine mailto [Université de Liège - ULg > Département de sciences des denrées alimentaires > Microbiologie des denrées alimentaires >]
Simon, Patricia mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Vanmanshoven, P. [> > > >]
Wagenaar, D. [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > Génomique animale >]
Feb-2000
Genome Research
10
2
220-7
Yes (verified by ORBi)
International
1088-9051
[en] linkage disequilibrium ; dairy cattle ; microsatellites
[en] A genome-wide linkage disequilibrium (LD) map was generated using microsatellite genotypes (284 autosomal microsatellite loci) of 581 gametes sampled from the dutch black-and-white dairy cattle population. LD was measured between all marker pairs, both syntenic and nonsyntenic. Analysis of syntenic pairs revealed surprisingly high levels of LD that, although more pronounced for closely linked marker pairs, extended over several tens of centimorgan. In addition, significant gametic associations were also shown to be very common between nonsyntenic loci. Simulations using the known genealogies of the studied sample indicate that random drift alone is likely to account for most of the observed disequilibrium. No clear evidence was obtained for a direct effect of selection ("Bulmer effect"). The observation of long range disequilibrium between syntenic loci using low-density marker maps indicates that LD mapping has the potential to be very effective in livestock populations. The frequent occurrence of gametic associations between nonsyntenic loci, however, encourages the combined use of linkage and linkage disequilibrium methods to avoid false positive results when mapping genes in livestock.
Researchers ; Professionals
http://hdl.handle.net/2268/8736

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