ORBi: Scippo Marie-Louise - Receptor-based screening assays: New perspectives in anti-doping control

Reference : Receptor-based screening assays: New perspectives in anti-doping control


	Document type :	Scientific journals : Article
	Discipline(s) :	Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/8707

Title :	Receptor-based screening assays: New perspectives in anti-doping control
Language :	English
Author, co-author :	Scippo, Marie-Louise [Université de Liège - ULg > Département de sciences des denrées alimentaires > Analyse des denrées alimentaires >]
	Willemsen, Philippe [> > > >]
	Danyi, Sophie [Université de Liège - ULg > Département de sciences des denrées alimentaires > Analyse des denrées alimentaires >]
	Helbo, Vincent [> > > >]
	Muller, Marc [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
	Martial, Joseph [Université de Liège - ULg > Département des sciences de la vie > Biologie et génétique moléculaire >]
	Maghuin-Rogister, Guy [Université de Liège - ULg > Département de sciences des denrées alimentaires > Département de sciences des denrées alimentaires >]
Publication date :	2004
Journal title :	Chromatographia
Publisher :	Vieweg
Volume :	59
Issue/season :	Suppl. S
Pages :	S23-S27
Audience :	International
ISSN :	0009-5893
City :	Wiesbaden
Keywords :	[en] receptor-based assays ; multianalyte control ; anti-doping control ; hormonal residues in food ; review
Abstract :	[en] The so-called "growth promoters", steroid hormones and beta-agonists, are currently controlled by using hyphenated analytical methods (chromatography coupled to mass spectrometry) or, sometimes for screening purposes, on immunoassays. These methods are often too specific to allow an effective multianalyte control. To develop more efficient assays, the use of hormonal receptors as detection tools (receptor-based binding assays and cell-based assays) is proposed. Receptor-based assays represent useful tools in screening of hormonal residues in food, but they could also be applied in doping control (to detect "new" hormonal substances). Furthermore, these assays could be used to monitor the human exposure to endocrine disruptors.
Permalink :	http://hdl.handle.net/2268/8707

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