Reference : Mathematical model of the acute inflammatory response to Escherichia coli in intramammar...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/8683
Mathematical model of the acute inflammatory response to Escherichia coli in intramammary challenge
English
Detilleux, Johann mailto [Université de Liège - ULg > Département de productions animales > Génétique quantitative >]
Vangroenweghe, F. [> > > >]
Burvenich, C. [> > > >]
2006
Journal of Dairy Science
Amer Dairy Science Assoc
89
9
3455-3465
Yes (verified by ORBi)
International
0022-0302
1525-3198
Savoy
[en] We constructed a mathematical model of the early response to Escherichia coli infection of the mammary gland and explored the roles and interactions between inflammatory cells and bacteria. The model incorporates 3 equations that describe the interactions among bacteria, milk somatic cells, and blood leukocyte densities. These 3 equations were fitted to cell densities observed during acute inflammatory responses in unvaccinated and vaccinated heifers inoculated with 10(4) or 10(6) cfu of E. coli. The rates computed for the cellular transit from the storage sites to the blood and from the blood to the milk were lower in cows receiving 10(4) cfu but increased at approximately 6 x 10(-6) and 30 x 10(-6) microL/cfu per h in nonvaccinated or vaccinated cows inoculated with 10(6) cfu, respectively. The cellular rates of bacterial killing were highest in unvaccinated cows ( approximately 400 x 10(-6) microL/cell per h) when compared with vaccinated cows (200 to 300 x 10(-6) microL/cell per h). A critical density of milk somatic cells at which bacteria density is constant was computed from the model at 2 x 10(6) cells/mL, and a one-way sensitivity analysis revealed that the changes in milk cellular densities were mostly sensitive to variations in the rate of bacterial killing and in the rate of production of inflammatory cells.
Researchers ; Professionals
http://hdl.handle.net/2268/8683

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