Reference : Brain plasticity related to the consolidation of motor sequence learning and motor adapt...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Brain plasticity related to the consolidation of motor sequence learning and motor adaptation
Debas, K. [> > > >]
Carrier, J. [> > > >]
Orban, Patricia [Universitéde Liège > Centre de Recherches du Cyclotron > > >]
Barakat, M. [> > > >]
Lungu, O. [> > > >]
Vandewalle, Gilles mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Hadj Tahar, A. [> > > >]
Bellec, P. [> > > >]
Karni, A. [> > > >]
Ungerleider, L. G. [> > > >]
Benali, H. [> > > >]
Doyon, J. [> > > >]
Proceedings of the National Academy of Sciences of the United States of America
National Academy of Sciences
[en] Adaptation, Physiological/*physiology ; Adult ; Brain/*physiology ; Female ; Humans ; Learning/*physiology ; Magnetic Resonance Imaging ; Male ; Motor Activity/*physiology ; Motor Skills/*physiology ; Neuronal Plasticity/*physiology ; Sleep/physiology ; Wakefulness/physiology
[en] This study aimed to investigate, through functional MRI (fMRI), the neuronal substrates associated with the consolidation process of two motor skills: motor sequence learning (MSL) and motor adaptation (MA). Four groups of young healthy individuals were assigned to either (i) a night/sleep condition, in which they were scanned while practicing a finger sequence learning task or an eight-target adaptation pointing task in the evening (test) and were scanned again 12 h later in the morning (retest) or (ii) a day/awake condition, in which they were scanned on the MSL or the MA tasks in the morning and were rescanned 12 h later in the evening. As expected and consistent with the behavioral results, the functional data revealed increased test-retest changes of activity in the striatum for the night/sleep group compared with the day/awake group in the MSL task. By contrast, the results of the MA task did not show any difference in test-retest activity between the night/sleep and day/awake groups. When the two MA task groups were combined, however, increased test-retest activity was found in lobule VI of the cerebellar cortex. Together, these findings highlight the presence of both functional and structural dissociations reflecting the off-line consolidation processes of MSL and MA. They suggest that MSL consolidation is sleep dependent and reflected by a differential increase of neural activity within the corticostriatal system, whereas MA consolidation necessitates either a period of daytime or sleep and is associated with increased neuronal activity within the corticocerebellar system.

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