ORBi: Gais Steffen - Sleep transforms the cerebral trace of declarative memories

Reference : Sleep transforms the cerebral trace of declarative memories


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Radiology, nuclear medicine & imaging Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/86816

Title :	Sleep transforms the cerebral trace of declarative memories
Language :	English
Author, co-author :	Gais, Steffen [> > > >]
	Albouy, Geneviève [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Boly, Mélanie [Université de Liège - ULg > Centre de Recherches du Cyclotron > Neurologie > > >]
	Dang Vu, Thien Thanh [Université de Liège - ULg > Centre de recherche du cyclotron > > > >]
	Darsaud, Annabelle [Université de Liège - ULg > Centre de recherche du cyclotron > > > >]
	Desseilles, Martin [Université de Liège - ULg > Département des sciences cliniques > Psychiatrie et psychologie médicale >]
	Rauchs, Geneviève [> > > >]
	Schabus, Manuel [Université de Liège - ULg > Centre de recherche du cyclotron > > > >]
	Sterpenich, Virginie [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Vandewalle, Gilles [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Maquet, Pierre [Université de Liège - ULg > > Centre de recherches du cyclotron]
	Peigneux, Philippe [Université de Liège - ULg > Centre de Recherches du Cyclotron > Département des sciences cognitives > >]
Publication date :	2007
Journal title :	Proceedings of the National Academy of Sciences of the United States of America
Publisher :	Natl Acad Sciences
Volume :	104
Issue/season :	47
Pages :	18778-18783
Audience :	International
ISSN :	0027-8424
e-ISSN :	1091-6490
City :	Washington
Country :	DC
Keywords :	[en] fMRI ; hippocampus ; Magnetic Resonance Imaging ; medial prefrontal cortex ; memory
Abstract :	[en] After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level.
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Fondation Medicale Reine Elisabeth ; Erwin Schro¨dinger fellowship of the Austrian Science Fund ; an Emmy Noether fellowship from the Deutsche Forschungsgemeinschaft
Permalink :	http://hdl.handle.net/2268/86816
	also: http://hdl.handle.net/2268/100794
DOI :	10.1073/pnas.0705454104
Other URL :	http://www.pnas.org cgi doi 10.1073 pnas.0705454104

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