Reference : Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine subst...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/86619
Molecular dissection of a quantitative trait locus: a phenylalanine-to-tyrosine substitution in the transmembrane domain of the bovine growth hormone receptor is associated with a major effect on milk yield and composition.
English
Blott, Sarah [> > > >]
Kim, Jong-Joo [> > > >]
Moisio, Sirja [> > > >]
Schmidt-Kuntzel, Anne [> > > >]
Cornet, Anne [Université de Liège - ULg > Département de morphologie et pathologie > Pathologie spéciale et autopsies >]
Berzi, Paulette mailto [Université de Liège - ULg > Services administratifs généraux > R&D : Gestion stratégique >]
Cambisano, Nadine mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Ford, Christine [> > > >]
Grisart, Bernard [> > > >]
Johnson, Dave [> > > >]
Karim, Latifa mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Simon, Patricia mailto [Université de Liège - ULg > > Centre d'ingénierie des protéines >]
Snell, Russell [> > > >]
Spelman, Richard [> > > >]
Wong, Jerry [> > > >]
Vilkki, Johanna [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Farnir, Frédéric mailto [Université de Liège - ULg > Département de productions animales > Biostatistiques et bioinformatique appliquées aux sc. vétér. >]
Coppieters, Wouter mailto [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
2003
Genetics
Genetics Society of America
163
1
253-66
Yes (verified by ORBi)
International
0016-6731
Baltimore
MD
[en] Amino Acid Substitution ; Animals ; Cattle ; Chromosome Mapping ; Haplotypes ; Linkage Disequilibrium ; Lod Score ; Microsatellite Repeats ; Milk/chemistry/metabolism ; Phenylalanine/metabolism ; Phylogeny ; Polymorphism, Genetic ; Quantitative Trait Loci ; Receptors, Somatotropin/genetics/metabolism ; Tyrosine/metabolism
[en] We herein report on our efforts to improve the mapping resolution of a QTL with major effect on milk yield and composition that was previously mapped to bovine chromosome 20. By using a denser chromosome 20 marker map and by exploiting linkage disequilibrium using two distinct approaches, we provide strong evidence that a chromosome segment including the gene coding for the growth hormone receptor accounts for at least part of the chromosome 20 QTL effect. By sequencing individuals with known QTL genotype, we identify an F to Y substitution in the transmembrane domain of the growth hormone receptor gene that is associated with a strong effect on milk yield and composition in the general population.
Professionals ; Researchers
http://hdl.handle.net/2268/86619
also: http://hdl.handle.net/2268/101935

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