Article (Scientific journals)
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.
Messaoudi, Samir; Anizon, Fabrice; Peixoto, Paul et al.
2006In Bioorganic and Medicinal Chemistry, 14 (22), p. 7551-62
Peer Reviewed verified by ORBi
 

Files


Full Text
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.pdf
Publisher postprint (394.67 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Animals; Aza Compounds/chemical synthesis/chemistry/pharmacology; Carbazoles/chemical synthesis/chemistry/pharmacology; Carbohydrates/chemistry; Cell Line, Tumor; Cell Proliferation/drug effects; DNA/metabolism; DNA Topoisomerases, Type I/metabolism; Enzyme Inhibitors/chemical synthesis/chemistry/pharmacology; Humans; Indoles/chemical synthesis/chemistry/pharmacology; Mice; Molecular Structure; Nitrogen/chemistry; Protein Kinases/metabolism; Pyridines/chemistry; Structure-Activity Relationship; Topoisomerase I Inhibitors
Abstract :
[en] The synthesis of a new family of 7-aza-rebeccamycin analogues in which the sugar moiety is attached to the nitrogen of the pyridine ring is described. The capacity of the newly synthesized compounds to bind to DNA and to inhibit topoisomerase I has been evaluated. Their cytotoxicities toward four tumor cell lines, one murine leukemia L1210 and three human tumor cell lines, one prostate carcinoma DU145, one colon carcinoma HT29, and one non-small cell lung carcinoma A549, have been determined. Their abilities to inhibit the checkpoint kinase Chk1 have been evaluated.
Disciplines :
Chemistry
Author, co-author :
Messaoudi, Samir
Anizon, Fabrice
Peixoto, Paul 
David-Cordonnier, Marie Hélène
Golsteyn, Roy M
Leonce, Stephane
Pfeiffer, Bruno
Prudhomme, Michelle
Language :
English
Title :
Synthesis and biological activities of 7-aza rebeccamycin analogues bearing the sugar moiety on the nitrogen of the pyridine ring.
Publication date :
2006
Journal title :
Bioorganic and Medicinal Chemistry
ISSN :
0968-0896
eISSN :
1464-3391
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
14
Issue :
22
Pages :
7551-62
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 March 2011

Statistics


Number of views
60 (2 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
24
Scopus citations®
without self-citations
18
OpenCitations
 
19

Bibliography


Similar publications



Contact ORBi