Reference : Comparison of inflammatory responses after off-pump and on-pump coronary surgery usin...
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/86435
Comparison of inflammatory responses after off-pump and on-pump coronary surgery using surface modifying additives circuit
English
Quaniers, Janine mailto [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Leruth, Julie [Centre Hospitalier Universitaire de Liège - CHU > > Urologie >]
Albert, Adelin [Université de Liège - ULg > Département des sciences de la santé publique > Informatique médicale et biostatistique >]
Limet, Raymond [Université de Liège - ULg > Département des sciences cliniques > Département des sciences cliniques >]
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie générale]
May-2006
Annals of Thoracic Surgery
Elsevier Science Inc
81
5
1683-1690
Yes (verified by ORBi)
International
0003-4975
1552-6259
New York
[en] Adult ; Peroxidase/blood ; Pancreatic Elastase/blood ; Leukocyte Count ; Neutrophils ; Middle Aged ; Male ; Complement Activation/physiology ; Interleukin-8/blood ; Interleukin-6/blood ; Interleukin-10/blood ; Humans ; Female ; Extracorporeal Circulation/methods ; Coronary Artery Bypass, Off-Pump/adverse effects ; Coronary Artery Bypass/adverse effects ; Aged, 80 and over ; Complement Membrane Attack Complex/analysis
[en] Background. Cardiac surgery is followed by various degrees of inflammation, which have harmful consequences. Because of the central role of extracorporeal circulation ( EC), off- pump coronary bypass surgery is deemed preferable. Do different modalities of EC challenge this view? Methods. Four groups of similar patients underwent coronary surgery: ( group 1) on- pump, EC with closed surface modifying additives ( SMA) circuit and no pump suckers ( n = 20); ( group 2) on- pump, EC with open SMA circuit and pump suckers ( n = 20); ( group 3) off- pump ( beating heart) and heparin 3 mg/ kg ( n = 20); ( group 4) off- pump ( beating heart) and heparin 1 mg/ kg ( n = 20). Interleukins ( IL)- 6, IL- 8, IL- 10, myeloperoxidase, elastase, and terminal complex of the complement ( TCC) were analyzed at various times: at induction ( time I); after heparin ( time II); after complete revascularization ( time III); after protamine ( time IV); and 24 hours later ( time V). Results. The TCC was significantly higher in groups 1 and 2 at time III. The pattern of IL- 6 was the same for the four groups. No significant difference in myeloperoxydase content was noted; however, elastase was significantly higher in the two EC ( on- pump) groups. Conclusions. Except for the complement system and elastase, on- pump surgery with SMA- coated circuits did not elicit any greater inflammatory response than off-pump surgery.
http://hdl.handle.net/2268/86435
also: http://hdl.handle.net/2268/117231
10.1016/j.athoracsur.2005.11.059

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