Article (Scientific journals)
Distribution of leucocyte subsets in bronchial mucosa from dogs with eosinophilic bronchopneumopathy
Peeters, Dominique; Day, M. J.; Clercx, Cécile
2005In Journal of Comparative Pathology, 133 (2-3, Aug-Oct), p. 128-135
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Keywords :
asthma; dog; eosinophilic bronchopneumopathy
Abstract :
[en] Immunohistochemistry was used to characterize the distribution of leucocyte subsets in the bronchial mucosa of 11 dogs with idiopathic eosinophilic bronchopneumopathy (EBP). Formalin-fixed tissues from all dogs were included in the study, but frozen tissue from only one dog was available. MHC class II(+) cells were found in moderate numbers in the lamina propria (LP). These cells were morphologically either dendritic-like cells or macrophages, but many macrophages did not express MHC class II. Such molecules were expressed by occasional fibroblasts. L1(+) cells, which formed a relatively small component of the LP inflammatory infiltrate, were morphologically either macrophages or polymorphonuclear cells (probably eosinophils). IgA(+) plasma cells were found in varying numbers in the LP, mostly in association with glandular tissue. IgG(+) plasma cells were less common, and IgM(+) plasma cells were present in low numbers. Many CD3(+) cells were present in the LP. In the single case from which frozen tissue was available, most of the lymphocytes were labelled with CD4 marker, while smaller numbers were CD8(+) T cells. Most of the lymphocytes in this case were positively labelled with T-cell receptor (TCR)-alphabeta marker. TCR-gammadelta(+) cells, although less common, were present in significant numbers throughout the LP. CDlc(+) dendritic cells were numerous in the epithelium and in the LP, immediately beneath the basement membrane. These findings, which were similar to those described in human asthma, are suggestive of a Th2 dominant immune response in canine EBP. As in human asthma, this provides a possible basis for new forms of treatment in canine EBP.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Peeters, Dominique ;  Université de Liège - ULiège > Clinique des petits animaux
Day, M. J.
Clercx, Cécile  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Pathologie médicale des petits animaux
Language :
English
Title :
Distribution of leucocyte subsets in bronchial mucosa from dogs with eosinophilic bronchopneumopathy
Publication date :
2005
Journal title :
Journal of Comparative Pathology
ISSN :
0021-9975
Publisher :
Academic Press Ltd Elsevier Science Ltd, London, United Kingdom
Volume :
133
Issue :
2-3, Aug-Oct
Pages :
128-135
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 March 2009

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