Article (Scientific journals)
Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
Laukens, Debby; Georges, Michel; Libioulle, Cécile et al.
2010In PLoS ONE, 5 (11), p. 13795
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Abstract :
[en] BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS: Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated with asthma and influences the expression of the ORMDL3 gene in lymphoblastoid cells, showed a significant association with AS (p = 0.03). In gut biopsies of AS and CD patients, ORMDL3 expression was not significantly different from controls and no correlation was found with the rs2872507 genotype (Spearman's rho: -0.067). The distribution of p-values for the remaining 36 SNPs was significantly skewed towards low p-values unless the top 5 ranked SNPs (ORMDL3, NKX2-3, PTPN2, ICOSLG and MST1) were excluded from the analysis. CONCLUSIONS: Association analysis using risk variants for CD led to the identification of a new risk variant associated with AS (ORMDL3), underscoring a role for ER stress in AS. In addition, two known and five potentially relevant associations were detected, contributing to common susceptibility of CD and AS.
Disciplines :
Genetics & genetic processes
Author, co-author :
Laukens, Debby
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Libioulle, Cécile  ;  Centre Hospitalier Universitaire de Liège - CHU > Génétique
Sandor, Cynthia ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Mni, Myriam ;  Université de Liège - ULiège > Département de productions animales > GIGA-R : Génomique animale
Vander Cruyssen, Bert
Peeters, Harald
Elewaut, Dirk
Devos, Martine ;  Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie
Language :
English
Title :
Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
Publication date :
2010
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, San Franscisco, United States - California
Volume :
5
Issue :
11
Pages :
e13795
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 February 2011

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