Reference : Evidence for significant overlap between common risk variants for Crohn's disease and...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/85227
Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
English
Laukens, Debby [> > > >]
Georges, Michel mailto [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Libioulle, Cécile mailto [Centre Hospitalier Universitaire de Liège - CHU > > Génétique >]
Sandor, Cynthia [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Mni, Myriam [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
Vander Cruyssen, Bert [> > > >]
Peeters, Harald [> > > >]
Elewaut, Dirk [> > > >]
Devos, Martine [Centre Hospitalier Universitaire de Liège - CHU > > Centre d'oncologie >]
2010
PLoS ONE
Public Library of Science
5
11
e13795
Yes (verified by ORBi)
International
1932-6203
San Franscisco
CA
[en] BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS: Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated with asthma and influences the expression of the ORMDL3 gene in lymphoblastoid cells, showed a significant association with AS (p = 0.03). In gut biopsies of AS and CD patients, ORMDL3 expression was not significantly different from controls and no correlation was found with the rs2872507 genotype (Spearman's rho: -0.067). The distribution of p-values for the remaining 36 SNPs was significantly skewed towards low p-values unless the top 5 ranked SNPs (ORMDL3, NKX2-3, PTPN2, ICOSLG and MST1) were excluded from the analysis. CONCLUSIONS: Association analysis using risk variants for CD led to the identification of a new risk variant associated with AS (ORMDL3), underscoring a role for ER stress in AS. In addition, two known and five potentially relevant associations were detected, contributing to common susceptibility of CD and AS.
http://hdl.handle.net/2268/85227
10.1371/journal.pone.0013795

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