[en] Cross-linking between peptide units in the wall peptidoglycan of Mycobacterium smegmatis 21732 ATCC is mediated through D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid linkages occurring in a ratio of about 2:1. The occurrence of D-alanyl-(D)-meso-diaminopimelic acid linkages was established by the action of the Streptomyces albus G DD-carboxypeptidase. The occurrence of meso-diaminopimelyl-meso-diaminopimelic acid
linkages was established by isolation from partial acid hydro-lysates and characterization by mass spectrometric analyses of the dipeptide meso-diaminopimelyl-meso-diaminopimelic acid and the tripeptide meso-diaminopimelyl-meso-diaminopimelyl-meso-diaminopimelic acid. meso-Diaminopimelyl-meso-diami-nopimelic acid interpeptide linkages also occur in the wall peptidoglycan of M. tuberculosis BCG Pasteur strain.
Fondation pour la Recherche Médicale ; New York Cancer Research Institut ; Fonds de la Recherche Fondamentale Collective