Reference : Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diam...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/85178
Occurrence of D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid interpeptide linkages in the peptidoglycan of Mycobacteria
English
Wietzerbin, Juana [Université Paris-Sud 11 > > > > >]
Das, Bhupsh C. [Centre National de la Recherche Scientifique - CNRS > > > > > >]
Petit, Jean-François [Université Paris-Sud 11 > > > >]
Lederer, Edgar [Université Paris-Sud 11 > > > > > >]
Leyh-Bouille, Mélina [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie > >]
Ghuysen, Jean-Marie [Université de Liège - ULg > Institut de Botanique > Service de Microbiologie > >]
13-Aug-1974
Biochemistry
American Chemical Society
13
17
3471-3476
Yes (verified by ORBi)
International
0006-2960
1520-4995
Washington
DC
[en] alanine analysis ; amino acids analysis ; amino acids dicarboxylic analysis ; carboxypeptidases ; cell wall analysis ; chemical phenomena ; chemistry ; dipeptides analysis isolation & purification ; electrophoresis paper ; glutamates analysis ; hydrogen-ion concentration ; hydrolysis ; mass spectrometry ; mitosporic fungi enzymology ; muramidase ; mycobacterium analysis ; mcobacterium tuberculosis analysis ; oligopeptides analysis solation & purification ; peptides ; peptidoglycan analysis ; pimelic acids analysis ; species specificity ; stereoisomerism ; streptomyces enzymology
[en] Cross-linking between peptide units in the wall peptidoglycan of Mycobacterium smegmatis 21732 ATCC is mediated through D-alanyl-(D)-meso-diaminopimelic acid and meso-diaminopimelyl-meso-diaminopimelic acid linkages occurring in a ratio of about 2:1. The occurrence of D-alanyl-(D)-meso-diaminopimelic acid linkages was established by the action of the Streptomyces albus G DD-carboxypeptidase. The occurrence of meso-diaminopimelyl-meso-diaminopimelic acid
linkages was established by isolation from partial acid hydro-lysates and characterization by mass spectrometric analyses of the dipeptide meso-diaminopimelyl-meso-diaminopimelic acid and the tripeptide meso-diaminopimelyl-meso-diaminopimelyl-meso-diaminopimelic acid. meso-Diaminopimelyl-meso-diami-nopimelic acid interpeptide linkages also occur in the wall peptidoglycan of M. tuberculosis BCG Pasteur strain.
Fondation pour la Recherche Médicale ; New York Cancer Research Institut ; Fonds de la Recherche Fondamentale Collective
Researchers ; Professionals
http://hdl.handle.net/2268/85178
10.1021/bi00714a008

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