Reference : Structure of the meso-diaminopimelic acid containing peptidoglycans in Escherichia co...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/85144
Structure of the meso-diaminopimelic acid containing peptidoglycans in Escherichia coli B and Bacillus megaterium KM
English
Van Heijenoort, Jean [> > > >]
Elbaz, Lydia [> > > >]
Dezelee, Philippe [> > > >]
Petit, Jean-François [> >]
Bricas, Evanghelos [> > > >]
Ghuysen, Jean-Marie [Université de Liège - ULg > > > Service de Bactériologie > >]
1-Jan-1969
Biochemistry
American Chemical Society
8
1
207-213
Yes (verified by ORBi)
International
0006-2960
1520-4995
Washington
DC
[en] Amino acid sequence ; amino acids ; bacillus megaterium ; cell wall ; chromatography ; electrophoresis ; escherichia coli ; glutamates ; peptide hydrolases ; peptides ; pimelic acids ; polysaccharides ; stereoisomerism ; streptomyces ; analysis ; thin layer ; bacterial
[en] The peptide subunit of the peptidoglycan of the envelope of Escherichia coli B has the sequence L-Ala-γ-D-Glu-(L)-meso-diaminopimelic acid-(L)-D-Ala. D-Ala-(D)-meso diaminopimelic acid linkages are involved in the cross-linking between peptide subunits. A major part of the wall peptidoglycan of Bacillus megaterium KM is composed of the same aforementioned peptide subunits and peptide cross-linkages. In this latter case, however, the D-Ala-(D)-meso-diaminopimelic acid linkages are not the only important ones. As previously shown, about 15% of the diaminopimelic acid residues are DD and they seem to be involved in another type of peptide cross-linkage. Streptomyces KM endopeptidase solubilizes the walls of Bacillus megaterium. Although this enzyme is not lytic upon Escherichia coli envelope, it liberates disaccharide peptide monomer from a bis-disaccharide peptide dimer, isolated from the same envelope. This dimer is composed of two β-1,4-N-acetylglucosaminyl-N-acetylmuramyl-L-Ala-γ-D-Glu-(L)-meso-diaminopimelic acid-(L)-D-Ala units, joined by a D-Ala-(D)-meso-diaminopimelic acid linkage.
Researchers ; Professionals
http://hdl.handle.net/2268/85144
10.1021/bi00829a030

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