ORBi: Quan X. - Genetic identification of distinct loci controlling mammary tumor multiplicity, latency and aggressiveness in the rat

Reference : Genetic identification of distinct loci controlling mammary tumor multiplicity, latency ...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Genetics & genetic processes Human health sciences : Oncology
	To cite this reference:	http://hdl.handle.net/2268/8507

Title :	Genetic identification of distinct loci controlling mammary tumor multiplicity, latency and aggressiveness in the rat
Language :	English
Author, co-author :	Quan, X. [ > > ]
	Laes, Jean-François [ > > ]
	Stieber, D. [ > > ]
	Rivière, M. [ > > ]
	Russo, J. [ > > ]
	Wedekind, D. [ > > ]
	Coppieters, Wouter [Université de Liège - ULg > Département de productions animales > Département de productions animales >]
	Farnir, Frédéric [Université de Liège - ULg > Département de productions animales > Biostatistique, économie, sélection animale >]
	Georges, Michel [Université de Liège - ULg > Département de productions animales > GIGA-R : Génomique animale >]
	Szpirer, J. [ > > ]
	Szpirer, C. [ > > ]
Publication date :	Apr-2006
Journal title :	Mammalian Genome : Official Journal of the International Mammalian Genome Society
Publisher :	Springer Verlag
Volume :	17
Issue/season :	4
Pages :	310-321
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0938-8990
e-ISSN :	1432-1777
City :	New York
Country :	NY
Keywords :	[en] Genetic ; Mammary tumor ; Rat
Abstract :	[en] The rat is considered an excellent model for studying human breast cancer. Therefore, understanding the genetic basis of susceptibility to mammary cancer in this species is of great interest. Previous studies based on crosses involving the susceptible strain WF (crossed with the resistant strains COP or WKY) and focusing on tumor multiplicity as the susceptibility phenotype led to the identification of several loci that control chemically induced mammary cancer. The present study was aimed to determine whether other loci can be identified by analyzing crosses derived from another susceptible strain on the one hand, and by including phenotypes other than tumor multiplicity on the other hand. A backcross was generated between the susceptible SPRD-Cu3 strain and the resistant WKY strain. Female progeny were genotyped with microsatellite markers covering all rat autosomes, treated with a single dose of DMBA, and phenotyped with respect to tumor latency, tumor multiplicity, and tumor aggressiveness. Seven loci controlling mammary tumor development were detected. Different loci control tumor multiplicity, latency, and aggressiveness. While some of these loci colocalize with loci identified in crosses involving the susceptible strain WF, new loci have been uncovered, indicating that the use of distinct susceptible and resistant strain pairs will help in establishing a comprehensive inventory of mammary cancer susceptibility loci
Target :	Researchers
Permalink :	http://hdl.handle.net/2268/8507

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