ORBi: Votion Dominique - Alveolar clearance in horses with chronic obstructive pulmonary disease

Reference : Alveolar clearance in horses with chronic obstructive pulmonary disease


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Veterinary medicine & animal health Life sciences : Anatomy (cytology, histology, embryology...) & physiology
	To cite this reference:	http://hdl.handle.net/2268/8497

Title :	Alveolar clearance in horses with chronic obstructive pulmonary disease
Language :	English
Author, co-author :	Votion, Dominique [Université de Liège - ULg > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux >]
	Vandenput, Sandrina [Université de Liège - ULg > CARE "Le Réseau des bibliothèques de l'ULg" > Bibliothèque des Sciences de la vie >]
	Duvivier, D. H. [> >]
	Lambert, Philippe [Université de Liège - ULg > Institut des sciences humaines et sociales > Méthodes quantitatives en sciences sociales]
	Van Erck, Emmanuelle [Université de Liège - ULg > Département clinique des animaux de production (DCP) > Département clinique des animaux de production (DCP) >]
	Art, Tatiana [Université de Liège - ULg > Département de sciences fonctionnelles > Phys. neuro-muscul., de l'effort - Méd. sport. des animaux >]
	Lekeux, Pierre [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >]
Publication date :	1999
Journal title :	American Journal of Veterinary Research
Publisher :	American Veterinary Medical Association
Volume :	60
Pages :	495-500
Audience :	International
ISSN :	0002-9645
City :	Schaumburg
Country :	IL
Keywords :	[en] pulmonary disease ; horses
Abstract :	[en] OBJECTIVE: To assess sensitivity of scintigraphic alveolar clearance rate as an indicator of alveolar epithelium damage in horses. ANIMALS: 5 healthy horses (group A) and 5 with chronic obstructive pulmonary disease (COPD; group B). PROCEDURE: Horses underwent clearance rate (k [%/min]) determination. Clearance rate of group-B horses was determined after remission of the disease following 2 months at pasture (remission 1), stabling in a controlled environment (remission 2), and during crisis induced by exposure to moldy hay and straw. Methacholine challenge test was performed at each investigation period to determine nonspecific pulmonary airway hyperresponsiveness. Pulmonary function tests (PFT) also were performed, and cell populations in bronchoalveolar lavage (BAL) fluid were determined on another occasion. RESULTS: Group-B horses had significantly faster mean clearance rate during crisis (k = 4.30+/-0.95%/min), compared with that for remission 1(k = 1.98+/-0.55%/min), which did not differ from the rate in group-A horses (k = 1.95+/-0.33%/min). Despite lack of clinical signs of COPD during remission when stabled in a controlled environment, an intermediate value was found (k = 3.20+/-0.72%/min). CONCLUSIONS: This technique allowed grading of lung damage induced by COPD, whereas use of PFT and determination of BAL fluid cell populations failed to differentiate between remission 1 and remission 2. CLINICAL RELEVANCE: Determination of alveolar clearance rate by use of scintigraphy is a sensitive indicator of lung damage. A modified clearance rate was found despite the lack of clinical and functional changes
Target :	Researchers ; Professionals ; Students
Permalink :	http://hdl.handle.net/2268/8497

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