Reference : Kinetic study of the antibody response during the blood meal of Ixodes ricinus: Implicat...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/84778
Kinetic study of the antibody response during the blood meal of Ixodes ricinus: Implication on plasma cell maturation in vivo and for anti-Ixodes vaccination
English
MENTEN, Catherine mailto [Université de Liège - ULg > > Centre d'oncologie >]
couvreur, B. [> >]
Jolois, Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Van Lerberghe, Pierre-Bernard mailto [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
Duwez, Luc mailto [Université de Liège - ULg > > GIGA-R : Services généraux de l'Université >]
Drion, Pierre mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]
Heinen, Ernst mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
18-Jan-2011
Vaccine
Elsevier Science
Yes
International
0264-410X
Amsterdam
The Netherlands
[en] Tick ; Vaccination ; Ixodes ; Ixodes ricinus ; mice ; BSA ; infestation ; antibody ; immune response ; B cells
[en] Anti-tick vaccination could be an ideal solution to prevent pathogen transmission, but none is currently available against Ixodes ticks. Recently, we showed that adult Ixodes ricinus infestation on mice decreases the specific antibody production to BSA injected during infestation. Here, a kinetic study of seric levels of BSA-specific antibodies was performed to evaluate the B memory cell differentiation in Balb/c mice and the capacity of specific B memory cells to respond to BSA during infestation. We concluded that the tick blood meal inhibits or impairs the local differentiation of mature B cells into plasma cells, but does not alter the formation of memory B cell. Accordingly, this mechanism should not be an impediment to anti-Ixodes vaccination.
Laboratory of Human Histology - Centre de recherche sur les protéines Prion (CRPP), University of Liege, Avenue de l'Hopital, 1, B-4000 Liege, Belgium.
Researchers ; Professionals
http://hdl.handle.net/2268/84778
http://www.ncbi.nlm.nih.gov/pubmed/21255683

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