ORBi: Menten Catherine - Kinetic study of the antibody response during the blood meal of Ixodes ricinus: Implication on plasma cell maturation in vivo and for anti-Ixodes vaccination

Reference : Kinetic study of the antibody response during the blood meal of Ixodes ricinus: Implicat...


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Immunology & infectious disease
	To cite this reference:	http://hdl.handle.net/2268/84778

Title :	Kinetic study of the antibody response during the blood meal of Ixodes ricinus: Implication on plasma cell maturation in vivo and for anti-Ixodes vaccination
Language :	English
Author, co-author :	Menten, Catherine [Université de Liège - ULg > > Centre d'oncologie >]
	couvreur, B. [> >]
	Jolois, Olivier [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
	Van Lerberghe, Pierre-Bernard [Université de Liège - ULg > Département des sciences cliniques > GIGA-R:Immunopath. - Maladies infect. et médec. inter. gén. >]
	Duwez, Luc [Université de Liège - ULg > > GIGA-R : Services généraux de l'Université >]
	Drion, Pierre [Université de Liège - ULg > Département des sciences biomédicales et précliniques > GIGA-R:Méth. expér.des anim. de labo et éth. en expér. anim. - GIGA-R : Services généraux de l'Université >]
	Heinen, Ernst [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Histologie humaine >]
Publication date :	18-Jan-2011
Journal title :	Vaccine
Publisher :	Elsevier Science
Peer reviewed :	Yes (verified by ORBi)
Audience :	International
ISSN :	0264-410X
City :	Amsterdam
Country :	The Netherlands
Keywords :	[en] Tick ; Vaccination ; Ixodes ; Ixodes ricinus ; mice ; BSA ; infestation ; antibody ; immune response ; B cells
Abstract :	[en] Anti-tick vaccination could be an ideal solution to prevent pathogen transmission, but none is currently available against Ixodes ticks. Recently, we showed that adult Ixodes ricinus infestation on mice decreases the specific antibody production to BSA injected during infestation. Here, a kinetic study of seric levels of BSA-specific antibodies was performed to evaluate the B memory cell differentiation in Balb/c mice and the capacity of specific B memory cells to respond to BSA during infestation. We concluded that the tick blood meal inhibits or impairs the local differentiation of mature B cells into plasma cells, but does not alter the formation of memory B cell. Accordingly, this mechanism should not be an impediment to anti-Ixodes vaccination.
Research units :	Laboratory of Human Histology - Centre de recherche sur les protéines Prion (CRPP), University of Liege, Avenue de l'Hopital, 1, B-4000 Liege, Belgium.
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/84778
Other URL :	http://www.ncbi.nlm.nih.gov/pubmed/21255683

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