[en] We report the prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in a 24-week-old fetus. Echographic features included cystic hygroma, a complex heart defect with right ventricular hypoplasia, and a large placental chorioangioma. We suggest that chorioangioma may be associated with chromosomal imbalance and that systematic careful morphologic examination of the fetus and karyotyping of any pregnancy in which large chorioangioma is detected is advisable. Jugular lymphatic obstruction sequence has not been reported so far in association with 4p-syndrome.
Disciplines :
Genetics & genetic processes
Author, co-author :
Verloes, Alain ; Université de Liège - ULiège > Génétique générale et humaine
Schaaps, Jean-Pierre ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Embryologie
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > PLAN COS
Soyeur, Daniel ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie
Hustin, J.
Dodinval, P.
Language :
English
Title :
Prenatal Diagnosis of Cystic Hygroma and Chorioangioma in the Wolf-Hirschhorn Syndrome
Publication date :
February 1991
Journal title :
Prenatal Diagnosis
ISSN :
0197-3851
eISSN :
1097-0223
Publisher :
John Wiley & Sons, Hoboken, United States - New Jersey
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