Reference : Nuclear Lesions During Rat Hepatocarcinogenesis. II. Measuring the Micronuclei During In...
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/84486
Nuclear Lesions During Rat Hepatocarcinogenesis. II. Measuring the Micronuclei During Initiation, Promotion and Progression of Rat Hepatocarcinogenesis Induced with Diethylnitrosamine
English
Herens, Christian mailto [Centre Hospitalier Universitaire de Liège - CHU > > PLAN COS >]
Massart, Sandrina mailto [Centre Hospitalier Universitaire de Liège - CHU > > Imagerie médicale >]
Bouzahzah, B. [> > > >]
Koulischer, Lucien [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Barbason, Hervé [Université de Liège - ULg > > Relations académiques et scientifiques (Médecine) >]
Jul-1995
Mutation Research : Fundamental & Molecular Mechanisms of Mutagenesis
329
2
161-71
Yes (verified by ORBi)
International
0027-5107
[en] We reported in our companion paper the strong correlation between elevated sister-chromatid exchange (SCE) frequencies and the initiation step of rat hepatocarcinogenesis. We have also shown that SCEs return to normal values during the promotion and the progression stages. In the present study, we evaluated the clastogenic activity of diethylnitrosamine (DEN) during initiation, promotion and progression of rat hepatocarcinogenesis. We measured, at various times after DEN administration, the number of micronuclei (MN) produced by the mitotic response to partial hepatectomy. The results established that the DEN treatment induces a great number of preclastogenic lesions. In subcarcinogenic conditions (initiation alone), the number of MN expressed after partial hepatectomy remains high regardless of the time interval between the end of the DEN treatment and the operation. In this condition, the preclastogenic lesions persist for up to 1 year after the DEN administration is discontinued. Conversely, in carcinogenic conditions (initiation + promotion + progression), the number of MN expressed after partial hepatectomy decreases during the promotion and progression stages. These observations indicate that promotion and progression but not initiation are associated with the expression of persistent preclastogenic lesions, resulting in the production of chromosomally abnormal hepatocytes.
http://hdl.handle.net/2268/84486

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