[en] Loss of the Y chromosome with a resulting 45, X0 karyotype is observed in normal bone marrow cells of elderly males but also in haematological malignancies. Whether Y loss in neoplastic cells is related to the process seen in normal ageing or is part of the carcinogenic process is unknown. The present study concerns the cytogenetic data from 1907 consecutive leukaemic or preleukaemic male patients with special regard to the presence or absence of the Y chromosome. Sixty-five patients (3.4%) had a 45, X-Y clone in their bone marrow (BM) cells. Loss of Y was rare below the age of 50 but increased in older patients, reaching 25% of the men over 80. Sixteen patients (0.08%) had more than 90% X0 cells in their BM. A correlation between Y loss and leukaemia could be established in seven cases, three of which were acute myeloid leukaemia M2 subtype where -Y is known to be a secondary event. In three other cases, -Y was part of a complex karyotype. Only one patient exhibited a 45, X0 karyotype, with no other rearrangement, that could be positively correlated with the neoplastic process.
Disciplines :
Genetics & genetic processes
Author, co-author :
Herens, Christian ; Centre Hospitalier Universitaire de Liège - CHU > PLAN COS
Brasseur, Edmond ; Centre Hospitalier Universitaire de Liège - CHU > Urgences
Jamar, Michelle ; Centre Hospitalier Universitaire de Liège - CHU > HOPITAL DE JOUR ONCOLOGIQUE SART TILMAN
Vierset, L.
Schoenen, I.
Koulischer, Lucien ; Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Loss of the Y Chromosome in Bone Marrow Cells: Results on 1907 Consecutive Cases of Leukaemia and Preleukaemia
Abe S., Golomb H.M., Rowley J.D., Mitelman F. & Sandberg A.A. (1980) Chromosomes and causation of human cancer and leukaemia. XXXV. The missing Y in acute non-lymphocytic leukaemia (ANLL). Cancer 45, 84-90.
Berger R. & Bernheim A. (1979) Y chromosome loss in leukaemia's. Cancer Genetics and Cytogenetics 1, 1-8.
Holmes R.I., Keating M.J., Cork A., Trujilio J.M., McCredie K.B. & Freireich E.J. (1985) Loss of the Y chromosome in acute myelogenous leukaemia. A Report of 13 Patients. Cancer Genetics and Cytogenetics 17, 269-278.
Kirk J.A., VanDevanter D.R., Biberman J. & Bryant E.M. (1994) Y chromosome loss in chronic myeloid leukaemia detected in both normal and malignant cells by interphase fluorescence in situ hybridization. Genes, Chromosomes and Cancer 11, 141-145.
Knapp R.H., Dewald G.W. & Pierre R.V. (1985) Cytogenctic studies in 174 consecutive patients with preleukemic or myelodysplastic syndromes. Mayo Clinical Proceedings 60, 507-516.
Kuffel D.G., Schultz C.G., Ash R.C. & DeWald G.W. (1991) Normal cytogenetic values for bone marrow cells based on studies of bone marrow transplant donors. Cancer Genetics and Cytogenetics 55, 39-48.
Mitelman F. (1991) Catalogue of Chromosome Aberrations in Cancer, 4th edn. Wiley Liss Inc.
Pierre R.V. & Hoagland H.C. (1972) Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with ageing. Cancer 30, 889-894.
Pugh W.C., Pearson M. & Vardimon J.W. (1985) Philadelphia chromosome negative chronic myelogenous leukaemia: a morphological reassessment. British Journal of Haematology 60, 457-460.
Riske C.B., Rodman M., Ondreyco S. & Sandberg A.A. (1994) X and Y chromosome loss as sole abnormality in acute nonlymphocytic leukaemia (ANLL). Cancer Genetics and Cytogenetics 72, 44-47.
Sakurai M. & Sandberg A.A. (1976) The chromosomes and causation of human cancer and leukaemia. XVIII. The missing Y in acute myeloblastic leukaemia (AML) and Ph-positive chronic myelocytic leukaemia (CML). Cancer 38, 762-769.
Stewart K., Carstairs K.C., Dube I.D. & Keating A. (1990) Neutrophilic myelofibrosis presenting as Philadelphia chromosome negative BCR non-rearranged chronic myeloid leukaemia. American Journal of Hematology 34, 59-63.
Stone J.F. & Sandberg A.A. (1995) Sex chromosome aneuploidy and aging. Mutation Research 338, 107-113.
Travis L.B., Pierre R.V. & DeWald G.W. (1986) Ph1 negative chronic granulocytic leukaemia: a nonentity. American Journal of Clinical Pathology 85, 186-192.
United Kingdom Cancer Cytogenetic Group (UKCCG) (1992) Loss of the Y chromosome from normal and neoplastic bone marrows. Genes, Chromosomes and Cancer 5, 83-88.