Reference : Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/84473
Malignant solitary fibrous tumor of the pleura: report of a case with cytogenetic analysis
English
Defraigne, Jean-Olivier mailto [Université de Liège - ULg > Département des sciences biomédicales et précliniques > Biochimie générale]
Hermans, Gilberte [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Dome, Florence [Centre Hospitalier Universitaire de Liège - CHU > > Anatomie pathologique >]
Herens, Christian mailto [Centre Hospitalier Universitaire de Liège - CHU > > PLAN COS >]
Apr-2003
Virchows Archiv
Springer-Verlag
442
4
388-392
Yes (verified by ORBi)
International
0945-6317
New York
[en] solitary fibrous tumor ; pleura ; cytogenetics ; tetrasomy 8 ; malignant
[en] The majority of solitary fibrous tumors (SFTs) of the pleura are benign, but 10-30% locally recur or metastasize. Pathogenic factors relevant to the determinism of their biological properties are largely unknown. Cytogenetic data on SFTs of the pleura are sparse. We report herein a case of a malignant SFT of the pleura where successful karyotyping was obtained from the primary and recurrent tumors. The initial karyotype showed two abnormal clones: 48, XY; +8; +8; del(9)(q22; q32) [19] and 46, XY, t(1; 16)(q25;p 12) [7]. Culture of the recurrent tumor yielded one clone identical to the dominant clone of the initial karyotype. Demonstration of a recurrent abnormal karyotype largely supports its relevance to the malignant clone and suggests a role of supernumerary chromosome(s) 8 in the determinism of malignant behavior in SFT.
http://hdl.handle.net/2268/84473

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