Reference : t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of t...
Scientific journals : Article
Human health sciences : Hematology
Human health sciences : Oncology
http://hdl.handle.net/2268/84472
t(5;14)/HOX11L2-positive T-cell acute lymphoblastic leukemia. A collaborative study of the Groupe Francais de Cytogenetique Hematologique (GFCH)
English
Berger, R. [> > > >]
Dastugue, N. [> > > >]
Busson, M. [> > > >]
van den Akker, J. [> > > >]
Perot, C. [> > > >]
Ballerini, P. [> > > >]
Hagemeijer, A. [> > > >]
Michaux, L. [> > > >]
Charrin, C. [> > > >]
Pages, M. P. [> > > >]
Mugneret, F. [> > > >]
Andrieux, J. [> > > >]
Talmant, P. [> > > >]
Helias, C. [> > > >]
Mauvieux, L. [> > > >]
Lafage-Pochitaloff, M. [> > > >]
Mozziconacci, M. J. [> > > >]
Cornillet-Lefebvre, P. [> > > >]
Radford, I. [> > > >]
Asnafi, V. [> > > >]
Bilhou-Nabera, C. [> > > >]
Khac, F. N. [> > > >]
Leonard, Colette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Comptabilité générale, budgétaire et analytique >]
Speleman, F. [> > > >]
Poppe, B. [> > > >]
Bastard, C. [> > > >]
Taviaux, S. [> > > >]
Quilichini, B. [> > > >]
Herens, Christian mailto [Centre Hospitalier Universitaire de Liège - CHU > > PLAN COS >]
Gregoire, M. J. [> > > >]
Cave, H. [> > > >]
Bernard, O. A. [> > > >]
Sep-2003
Leukemia
Nature Publishing Group
17
9
1851-1857
Yes (verified by ORBi)
0887-6924
London
[en] acute lymphoblastic leukemia ; T-cell ALL ; t(5 ; 14) ; HOX11L2
[en] To accurately estimate the incidence of HOX11L2 expression, and determine the associated cytogenetic features, in T-cell acute lymphoblastic leukemia (T-ALL), the Groupe Francais de Cytogenetique Hematologique (GFCH) carried out a retrospective study of both childhood and adult patients. In total, 364 patients were included ( 211 children less than or equal to15 years and 153 adults), and 67 ( 18.5%) [ 47 children ( 22.4%) and 20 adults (13.1%)] were shown to either harbor the t(5; 14) q35; q32) translocation or express the HOX11L2 gene or both. Most of the common hematological parameters did not show significant differences within positive and negative populations, whereas the incidence of CD1a+/CD10+ and cytoplasmic CD3+ patients was significantly higher in positive than in negative children. Out of the 63 positive patients investigated by conventional cytogenetics, 32 exhibited normal karyotype, whereas the others 31 showed clonal chromosome abnormalities, which did not include classical T-ALL specific translocations. Involvement of the RANBP17/HOX11L2 locus was ascertained by fluorescence in situ hybridization in six variant or alternative (three-way translocation or cytogenetic partner other than 14q32) translocations out of the 223 patients. Our results also show that HOX11L2 expression essentially occurs as a result of a 5q35 rearrangement, but is not associated with another identified T-ALL specific recurrent genetic abnormality, such as SIL-TAL fusion or HOX11 expression.
http://hdl.handle.net/2268/84472

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