Article (Scientific journals)
Recent insights into Protein Phosphatase 2A structure and regulation : The reason why PP2A is no longer considered as a lazy passive housekeeping enzyme
Martin, Maud; Kettmann, Richard; Dequiedt, Franck
2010In Biotechnologie, Agronomie, Société et Environnement, 14 (1), p. 243-252
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Keywords :
PP2A; structure; regulatory subunits
Abstract :
[en] Reversible protein phosphorylation is a major intracellular mechanism for controlling many important physiological activities. In the past, most of the attention was focused primarily on protein kinases and on their regulation, mainly because phosphatases were then viewed as simple housekeeping enzymes. But advances in the understanding of phosphatases make now clear that protein phosphatases are dynamic and highly regulated enzymes and are as important as kinases in the regulation of cellular processes involving protein phosphorylation. Protein phosphatase 2A (PP2A) is a very abundant -it accounts for as much as 1% of total cellular protein-, ubiquitous and remarkably conserved enzyme. By dephosphorylating a plethora of cellular proteins, it is involved in the regulation of nearly all cellular activities.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Martin, Maud ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Kettmann, Richard ;  Université de Liège - ULiège > Chimie et bio-industries > Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Dequiedt, Franck  ;  Université de Liège - ULiège > GIGA-Research - Centre de Bio. Fond. - Section de Biologie cell. et moléc.
Language :
English
Title :
Recent insights into Protein Phosphatase 2A structure and regulation : The reason why PP2A is no longer considered as a lazy passive housekeeping enzyme
Publication date :
2010
Journal title :
Biotechnologie, Agronomie, Société et Environnement
ISSN :
1370-6233
eISSN :
1780-4507
Publisher :
Presses Agronomiques de Gembloux, Gembloux, Belgium
Volume :
14
Issue :
1
Pages :
243-252
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 February 2011

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