ORBi: Bruno Marie-Aurélie - Disorders of consciousness: Moving from passive to resting state and active paradigms

Reference : Disorders of consciousness: Moving from passive to resting state and active paradigms


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Neurology
	To cite this reference:	http://hdl.handle.net/2268/83873

Title :	Disorders of consciousness: Moving from passive to resting state and active paradigms
Language :	English
Author, co-author :	Bruno, Marie-Aurélie [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science group > >]
	Soddu, Andrea [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science group > >]
	Demertzi, Athina [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Laureys, Steven [Université de Liège - ULg > Centre de recherches du cyclotron - Département des sciences cliniques > Coma Science Group > >]
	Gosseries, Olivia [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science Group > >]
	Schnakers, Caroline [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Boly, Mélanie [Université de Liège - ULg > Centre de Recherches du Cyclotron - Coma Science Group > Département des sciences cliniques - Neurologie > >]
	Noirhomme, Quentin [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Thonnard, Marie [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Chatelle, Camille [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Vanhaudenhuyse, Audrey [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science Group > >]
Publication date :	2010
Journal title :	Cognitive Neuroscience
Publisher :	Taylor & Francis
Volume :	1
Issue/season :	1
Pages :	193–203
Audience :	International
ISSN :	1758-8928
e-ISSN :	1758-8936
City :	Cambridge
Country :	United Kingdom
Keywords :	[en] Consciousness ; Vegetative state ; Resting state ; fMRI ; Active paradigms
Abstract :	[en] Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e., minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state. The increasing use of fMRI and EEG tools permits the clinical characterization of these patients to be improved. We first discuss “resting metabolism” and “passive activation” paradigms, used in neuroimaging and evoked potential studies, which merely identify neural activation reflecting “automatic” processing—that is, occurring without the patient’s willful intervention. Secondly, we present an alternative approach consisting of instructing subjects to imagine well-defined sensorymotor or cognitive-mental actions. This strategy reflects volitional neural activation and, hence, witnesses awareness. Finally, we present results on blood-oxgen-level-dependent “default mode network”/resting state studies that might be a promising tool in the diagnosis of these challenging patients.
Research units :	Centre de Recherches du Cyclotron - CRC
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; European Commission ; Concerted Research Action (ARC-06/11-340) ; The McDonnell Foundation ; Mind Science Foundation.
Permalink :	http://hdl.handle.net/2268/83873
DOI :	10.1080/17588928.2010.485677
Other URL :	http://dx.doi.org/10.1080/17588928.2010.485677

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