Reference : Disorders of consciousness: Moving from passive to resting state and active paradigms
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/83873
Disorders of consciousness: Moving from passive to resting state and active paradigms
English
Bruno, Marie-Aurélie mailto [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science group > >]
Soddu, Andrea [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science group > >]
Demertzi, Athina [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Laureys, Steven mailto [Université de Liège - ULg > Centre de recherches du cyclotron - Département des sciences cliniques > Coma Science Group > >]
Gosseries, Olivia [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science Group > >]
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Boly, Mélanie mailto [Université de Liège - ULg > Centre de Recherches du Cyclotron - Coma Science Group > Département des sciences cliniques - Neurologie > >]
Noirhomme, Quentin [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Thonnard, Marie [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Chatelle, Camille [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > Centre de recherches du cyclotron > Coma Science Group > >]
2010
Cognitive Neuroscience
Taylor & Francis
1
1
193–203
Yes (verified by ORBi)
International
1758-8928
1758-8936
Cambridge
United Kingdom
[en] Consciousness ; Vegetative state ; Resting state ; fMRI ; Active paradigms
[en] Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or
may show nonreflexive movements but with no ability for functional communication (i.e., minimally conscious
state). Currently, there remains a high rate of misdiagnosis of the vegetative state. The increasing use of fMRI and
EEG tools permits the clinical characterization of these patients to be improved. We first discuss “resting metabolism”
and “passive activation” paradigms, used in neuroimaging and evoked potential studies, which merely identify
neural activation reflecting “automatic” processing—that is, occurring without the patient’s willful intervention.
Secondly, we present an alternative approach consisting of instructing subjects to imagine well-defined sensorymotor
or cognitive-mental actions. This strategy reflects volitional neural activation and, hence, witnesses awareness.
Finally, we present results on blood-oxgen-level-dependent “default mode network”/resting state studies that
might be a promising tool in the diagnosis of these challenging patients.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; European Commission ; Concerted Research Action (ARC-06/11-340) ; The McDonnell Foundation ; Mind Science Foundation.
http://hdl.handle.net/2268/83873
10.1080/17588928.2010.485677
http://dx.doi.org/10.1080/17588928.2010.485677

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