Reference : Breakdown of within- and between-network resting state functional magnetic resonance ima...
Scientific journals : Article
Human health sciences : Neurology
http://hdl.handle.net/2268/83850
Breakdown of within- and between-network resting state functional magnetic resonance imaging connectivity during propofol-induced loss of consciousness.
English
Boveroux, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Vanhaudenhuyse, Audrey mailto [Université de Liège - ULg > > Centre de recherches du cyclotron > > Coma Science Group > >]
Bruno, Marie-Aurélie mailto [Université de Liège - ULg > > Centre de recherches du cyclotron > > Coma Science Group > >]
Noirhomme, Quentin [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Lauwick, Séverine [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Luxen, André [Université de Liège - ULg > Centre de recherches du cyclotron Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron > > >]
Degueldre, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Plenevaux, Alain [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Schnakers, Caroline mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Phillips, Christophe [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Brichant, Jean-François mailto [Université de Liège - ULg > Département des sciences cliniques > Anesthésie et réanimation >]
Bonhomme, Vincent [Centre Hospitalier Universitaire de Liège - CHU > > Anesthésie et réanimation >]
Maquet, Pierre [Université de Liège - ULg > Centre de reherches du cyclotron > Neurologie Sart Tilman > > >]
Greicius, Michael D [> > > >]
Laureys, Steven mailto [Université de Liège - ULg > > Centre de recherches du cyclotron - Département des sciences cliniques >]
Boly, Mélanie mailto [Université de Liège - ULg > Centre de recherches du cyclotron - Coma group Département des sciences cliniques > Neurologie > > >]
2010
Anesthesiology
Lippincott Williams & Wilkins
113
5
1038-53
Yes (verified by ORBi)
International
0003-3022
1528-1175
Philadelphia
PA
[en] Adolescent ; Adult ; Conscious Sedation/methods ; Consciousness/drug effects/physiology ; Deep Sedation/methods ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Nerve Net/drug effects/physiology ; Propofol/pharmacology ; Rest/physiology ; Unconsciousness/chemically induced/physiopathology ; Young Adult
[en] BACKGROUND: Mechanisms of anesthesia-induced loss of consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation of the level of consciousness. METHODS: Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers during wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery of consciousness. RESULTS: Propofol-induced decrease in consciousness linearly correlates with decreased corticocortical and thalamocortical connectivity in frontoparietal networks (i.e., default- and executive-control networks). Furthermore, during propofol-induced unconsciousness, a negative correlation was identified between thalamic and cortical activity in these networks. Finally, negative correlations between default network and lateral frontoparietal cortices activity, present during wakefulness, decreased proportionally to propofol-induced loss of consciousness. In contrast, connectivity was globally preserved in low-level sensory cortices, (i.e., in auditory and visual networks across sedation stages). This was paired with preserved thalamocortical connectivity in these networks. Rather, waning of consciousness was associated with a loss of cross-modal interactions between visual and auditory networks. CONCLUSIONS: Our results shed light on the functional significance of spontaneous brain activity fluctuations observed in functional magnetic resonance imaging. They suggest that propofol-induced unconsciousness could be linked to a breakdown of cerebral temporal architecture that modifies both within- and between-network connectivity and thus prevents communication between low-level sensory and higher-order frontoparietal cortices, thought to be necessary for perception of external stimuli. They emphasize the importance of thalamocortical connectivity in higher-order cognitive brain networks in the genesis of conscious perception.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
http://hdl.handle.net/2268/83850
also: http://hdl.handle.net/2268/78335
10.1097/ALN.0b013e3181f697f5

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