Reference : Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/83796
Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
English
Bellon, B. [ > > ]
Capron, M. [ > > ]
Druet, E. [ > > ]
Verroust, P. [ > > ]
Vial, M. C. [ > > ]
Sapin, C. C. [ > > ]
Girard, J. F. [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Mahieu, P. [ > > ]
Druet, P. [ > > ]
1982
European Journal of Clinical Investigation
Blackwell Publishing
12
2
127-33
Yes (verified by ORBi)
International
0014-2972
1365-2362
Oxford
United Kingdom
[en] Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.
http://hdl.handle.net/2268/83796

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