ORBi: Bellon B. - Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.

Reference : Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/83796

Title :	Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
Language :	English
Author, co-author :	Bellon, B. [ > > ]
	Capron, M. [ > > ]
	Druet, E. [ > > ]
	Verroust, P. [ > > ]
	Vial, M. C. [ > > ]
	Sapin, C. C. [ > > ]
	Girard, J. F. [ > > ]
	Foidart, Jean-Michel [Université de Liège - ULg > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
	Mahieu, P. [ > > ]
	Druet, P. [ > > ]
Publication date :	1982
Journal title :	European Journal of Clinical Investigation
Publisher :	Blackwell Publishing
Volume :	12
Issue/season :	2
Pages :	127-33
Audience :	International
ISSN :	0014-2972
e-ISSN :	1365-2362
City :	Oxford
Country :	United Kingdom
Abstract :	[en] Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.
Permalink :	http://hdl.handle.net/2268/83796

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