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Article (Scientific journals)
Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
Bellon, B.; Capron, M.; Druet, E. et al.
1982In European Journal of Clinical Investigation, 12 (2), p. 127-33
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Abstract :
[en] Mercuric chloride induces in the Brown-Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti-glomerular basement membrane antibodies and immune complex-like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti-glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti-glomerular basement membrane antibodies and of circulating immune complexes, although HgCl2 injections were pursued, is in agreement with the self-limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bellon, B.
Capron, M.
Druet, E.
Verroust, P.
Vial, M. C.
Sapin, C. C.
Girard, J. F.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Mahieu, P.
Druet, P.
Language :
English
Title :
Mercuric chloride induced autoimmune disease in Brown-Norway rats: sequential search for anti-basement membrane antibodies and circulating immune complexes.
Publication date :
1982
Journal title :
European Journal of Clinical Investigation
ISSN :
0014-2972
eISSN :
1365-2362
Publisher :
Blackwell Publishing, Oxford, United Kingdom
Volume :
12
Issue :
2
Pages :
127-33
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 February 2011

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