Distribution of laminin, a basement membrane glycoprotein in epithelial proliferations. A preliminary study in the breast, the lungs and uterine cervix.
Birembaut, P.; Caron, Y.; Van Cauwenberge, D.et al.
1983 • In Collagen and Related Research, 3 (1), p. 25-31
[en] Distribution of laminin, a basement membrane glycoprotein, was studied by an indirect immunofluorescence technique in benign, dysplastic and malignant lesions of breast, lungs and uterine cervix as compared with normal tissues. Laminin was present with a linear and continuous staining in epithelial and vascular basement membranes in normal tissues, benign and dysplastic lesions and in in situ carcinomas of the uterine cervix. By contrast, laminin was absent or very irregularly distributed around malignant infiltrating tumoral clusters. Of particular interest was the linear and disrupted labeling observed in intra-epithelial carcinomas of breast and bronchi. Loss of laminin in these conditions could be related to a potential tumoral invasion.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Birembaut, P.
Caron, Y.
Van Cauwenberge, D.
Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Language :
English
Title :
Distribution of laminin, a basement membrane glycoprotein in epithelial proliferations. A preliminary study in the breast, the lungs and uterine cervix.
Aalto M. Potila M. Kulonen E. The effect of silica-treated macrophages on the synthesis of collagen and other proteins in vitro Exp. Cell Res. 97 1976 193 202
Abe S. Steinmann B.U. Wahl L.M. Martin G.R. High cell density alters the ratio of type III to I collagen synthesis by fibroblasts Nature 279 1979 442 444
Attström R. Schroeder H.E. The effect of experimental neutropenia on initial gingivitis in dogs Scand. J. Dent. Res. 87 1979 7 23
Avery B.E. Simpson D.M. The baboon as a model system of periodontal disease; clinical and light microscopic observations J. Periodontol. 44 1973 675 686
Bailey A.J. Sims T.J. Le Lous M. Bazin S. Collagen polymorphism in experimental granulation tissue Biochem. Biophys. Res. Comm. 66 1975 1160 1165
Ballard J.B. Butler W.T. Proteins of the periodontium. Biochemical studies on the collagen and noncollagenous proteins of human gingivae J. Oral Path. 3 1974 176 184
Baum B.J. Moss J. Breul S.D. Berg R.A. Crystal R.G. Effect of cyclic AMP on the intracellular degradation of newly synthesized collagen J. Biol. Chem. 255 1980 2843 2847
Baum B.J. Moss J. Breul S.D. Crystal R.G. Association in normal human fibroblasts of elevated levels of adenosine 3:5-monophosphate with a selective decrease in collagen production J. Biol. Chem. 253 1978 3391 3394
Bergenholtz A. Hänström L. The effect of diphenylhydantoin upon the biosynthesis and degradation of collagen in cat palatal mucosa in organ culture Biochem. Pharmacol. 28 1979 2653 2659
Birkedal-Hansen H. Butler W.T. Taylor R.E. Proteins of the periodontium. Characterization of the insoluble collagens of bovine dental cementum Calcif. Tiss. Res. 23 1977 39 44
Birkedal-Hansen H. Cobb C.M. Taylor R.E. Fullmer H.M. Fibroblastic origin of bovine gingival collagenase Arch. Oral Biol. 21 1976 297 305
Bienkowski R.S. Baum B.J. Crystal R.G. Fibroblasts degrade newly synthesized collagen within the cell before secretion Nature 276 1978 a 413 416
Bienkowski R.S. Cowan M.J. McDonald J.A. Crystal R.G. Degradation of newly synthesized collagen J. Biol. Chem. 253 1978 b 4356 4363
Bordin, S., Kolb, W. B. and Page, R.C.: C1q receptors in cultured human diploid fibroblasts analysis of binding properties. J. Immunol. In Press. 1982.
Bornstein P. Sage H. Structurally distinct collagen types Ann. Rev. Biochem. 49 1980 957 1003
Burke J.M. Balian G. Ross R. Bornstein P. Synthesis of types I and III procollagens and collagen by monkey aortic smooth muscle cells in vitro Biochemistry 16 1977 3243 3249
Butler W.T. Birkedal-Hansen H. Beegle W.F. Taylor R.E. Chung E. Proteins of the periodontium. Identification of collagens with the [α1(1)]2 α2 and [α1(III)]3 structures in bovine periodontal ligament J. Biol. Chem. 250 1975 a 8907 8912
In Butler W.T. Birkedal-Harisen H. Taylor R.E. Proteins of the periodontium. The chain structure of the collagens of bovine cementum and periodontal ligament ed by H.C. Slavkin R.C. Greulick Extracellular Influence on Gene Expression 1975 b Academic Press 371 377
Carneiro J. Synthesis and turnover of collagen in peridontal tissues Symp. Int. Soc. Cell Biol. 4 1965 247 257
Carpenter G. Epidermal growth factor Ann. Rev. Biochem. 48 1979 193 216
Christner P. Robinson P. Clark C.C. A preliminary characterization of human cementum collagen Calcil. Tiss. Res. 23 1977 147 150
Ciancio S.G. Mather M.L. Acid mucopolysaccharides in gingivitis and periodontitis J. Periodont. Res. 6 1971 188 193
Claycomb C.K. Summers G.W. Dvorak E.M. Oral collagen biosynthesis in the guinea pig J. Periodont. Res. 2 1967 115 120
Dabbous M.K. Hammouda O. Brinkley S.B. Isolation and partial characterization of bovine gingival A B collagen Mol. Cell. Biochem. 34 1981 87 93
Dayer J.-M. Stephenson M.L. Schmidt E. Kargi N. Krane S.M. Purification of a factor from human blood mono cyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rhe FEBS Lett. 124 1981 253 256
Deshmukh K. Nimni M.E. Effects of lysosomal enzymes on the type of collagen synthesized by bovine articular cartilage Biochem. Biophys. Res. Comm. 53 1973 424 431
Deshmukh K. Sawyer B.D. Synthesis of collagen by chondrocytes in suspension culture: Modulation by calcium, 3:5-cyclic AMP, and prostaglandins Proc. Natl. Acad. Sci. USA 74 1977 3864 3868
Deshmukh K. Sawyer B.D. Influence of extracellular pyrophosphate on the synthesis of collagen by chondrocytes FEBS Lett. 89 1978 230 232
El Attar T.M.A. Prostaglandin E2 in human gingiva in health and disease and its stimulation by female sex steroids Prostaglandins 11 1976 331 339
El Attar T.M.A. in H.S. Prostaglandins in gingiva of patients with periodontal disease J. Periodontol. 52 1981 16 19
Embery G. Oliver W.M. tanbury J.B. The metabolism of proteoglycans and glycosaminoglycans in inflamed human gingiva J. Periodont. Res. 14 1979 512 519
Engel L.D. Schroeder H.E. Page R.C. Morphologic features and functional properties of human fibroblasts exposed to Actinomyces viscosus substances Infect. Immunity 19 1978 287 297
Gadek J.E. Fells G.A. Wright D.G. Crystal R.G. Human neutrophil elastase functions as a type III collagen “Collagenase” Biochem. Biophys. Res. Comm. 95 1980 1815 1822
Gay S. Müller P.K. Lemmen C. Remberger K. Matzen K. Kühn K. Immunohistological study on collagen in cartilage-bone metamorphosis and degenerative osteoarthritis Klin. Wschr. 54 1976 969 976
Gay S. Viljanto J. Raekallio H. Penttinen R. Collagen types in early phases of wound healing in children Acta Chir. Scand. 144 1978 205 211
Goggins J.F. Fullmer H.M. Steffek A.J. Hyaluronidase activity of human gingiva Arch. Path. 85 1968 272 274
Goodson J.M. Dewhirst F.E. Brunetti A. Prostaglandin E2 levels and human periodontal disease Prostaglandins 6 1974 81 85
Gospodarowicz D. Moran J.S. Growth factors in mammalian cell culture Ann. Rev. Biochem. 45 1976 531 558
Goultschin J. Shoshan S. Inhibition of collagen breakdown by diphenylhydantoin Biochem. Biophys. Acta 631 1980 188 191
Granger A.G. Lymphokines — The mediators of cellular immunity Wer. Haematol. 5 1972 8 40
Granger G.A. Yamamoto R.S. Fair D.S. Hiserodt J.C. Physical-chemical heterogeneity of LT molecules released by mitogen activated human lymphocytes in vitro Cell. Immunol. 38 1978 388 402
Abs. No. 965 Hammouda O. Brinkley B. Sr. abbous M.K. Gingival type V collagen Fed. Proc. 39 1980 1789
Hassell T.M. Collagenase activity is inhibited in fibroblasts from phenytoin-induced gingival overgrowth J. Dent. Res. 61 1982 275
Hassell T.M. Page R.C. Lindhe J. Histologic evidence for impaired growth control in Diphenylhydantoin gingival overgrowth in man Arch. Oral Biol. 23 1978 381 384
Hassell T.M. Page R.C. Narayanan A.S. Cooper G.C. Diphenylhydantoin (Dilantin) gingival hyperplasia: Drug-induced abnormality of connective tissue Proc. Natl. Acad. Sci. USA 73 1976 2909 2912
Hassell, T. M., Roebuck, S., and Page, R.C.: Quantitative histopathologic assessment of developing phenytoin-induced gingival overgrowth in the cat. J. Clin. Periodontol. , in press, 1982.
Hata R.-I. Slavkin H.C. De novo induction of a gene product during heterologous epithelial-mesenchymal interactions in vitro Proc. Natl. Acad. Sci. USA 75 1978 2790 2794
Hauck J.C. Sharma V.K. Hayflick L. Functional failures of cultured human diploid fibroblasts after continued population doublings Proc. Soc. Exp. Biol. Med. 137 1971 331 333
Hershko A. Mamont P. Shields R. Tomkins G.M. Pleiotypic response Nature New Biology 232 1971 206 211
Hiramatsu M. Abe I. Minami N. Acid mucopolysaccharides in porcine gingiva J. Periodont. Res. 13 1978 224 231
Holley R.W. Control of growth of mammalian cells in cell culture Nature 258 1975 487 4905
Horwitz A.L. Hance A.J. Crystal R.G. Granulocyte collagenase: Selective digestion of type I relative to type III collagen Proc. Nat. Acad. Sci. USA 74 1977 897 901
Huey J. Narayanan A.S. Jones K. Page R.C. Effect of epidermal growth factor on the synthetic activity of human fibroblasts Biochim. Biophys. Acta 632 1980 227 233
Ishikawa J. Glickman I. Gingival response to the systemic administration of sodium diphenylhydantoin (Dilantin) in cats J. Periodontol. 32 1961 149 158
Jeffes E.W.B. III Granger G.A. Relationship of CIF, LT, and PIF released in vitro by activated human lymphocytes. II. A further functional comparison of LT and PIF activities on HeLa an J. Immunol. 117 1976 174 179
Jimenez S.A. McArthur W. Rosenbloom J. Inhibition of collagen synthesis by mononuclear cell supernates J. Exp. Med. 150 1979 1421 1431
Johnson, B., El-Guindy, M., Ammons, W.F., Narayanan, A.S., and Page, R.C.: A defect in fibroblasts from an unidentified syndrome with gingival hyperplasia as the predominant feature. J. Periodont. Res. 1982, submitted.
Johnson R.L. Ziff M. Lymphokine stimulation of collagen accumulation J. Cell. Immunol. 58 1976 240 252
Kameyama Y. Autoradiographic study of 3H-proline incorporation by rat periodontal ligament, gingival connective tissue and dental pulp J. Periodont. Res. 10 1975 98 102
Kaufman M. Pinsky L. Straisfeld L. Shanfield B. Zilahi B. Qualitative differences in testosterone metabolism as an indication of cellular heterogeneity in fibroblast monolayers derived from human preputial skin Exp. Cell Res. 96 1975 31 34
King J.D. Experimental production of gingival hyperplasia in Ferrets given “EPANUTIN” (sodium diphenylhydantoinate) Br. J. Exp. Path. 33 1952 491 498
Ko S.D. Narayanan A.S. Page R.C. Influence of cell cycle on collagen synthesis by human gingival fibroblasts J. Periodont. Res. 16 1981 302 308
Ko S.D. Page R.C. Narayanan A.S. Fibroblast heterogeneity and prostaglandin regulation of subpopulation Proc. Natl. Acad. Sci. USA 74 1977 3429 3432
Kobayshi I. Ziff M. Electron microscopic studies of lymphoid cells in rheumatoid synovial membrane Arthr. Rheum. 16 1973 471 486
Korn J.H. Halushka P.V. LeRoy E.L. Mononuclear cell modulation of connective tissue function: Suppression of fibroblast growth by stimulation of endogenous prostaglandin production J. Clin. Invest. 65 1980 543 554
Korotzer T.I. Clagett J.A. Kolb W.F. Page R.C. Complement dependent induction of DNA synthesis and proliferation of human diploid fibroblasts J. Cell Physiol. 105 1980 503 512
Korotzer T.I. Page R.C. Granger G.A. Rabinovitch P.S. Regulation of growth of human diploid fibroblasts by factors elaborated by activated lymphoid cells J. Cell Physiol. 111 1982 247 254
Kuboki Y. Takagi T. Sasaki S. Saito S. Mechanic G.L. Comparative collagen biochemistry of bovine periodontium, gingiva and dental pulp J. Dent. Res. 60 1981 159 163
Lee S.-C. Lucas Z.J. Regulatory factors produced by lymphocytes: II. initiation of cellular DNA synthesis associated with a factor inhibiting DNA alpha polymerase activity J. Immunol. 118 1977 88 97
Leibovich S.J. Ross R. A macrophage-dependent factor that stimulates the proliferation of fibroblasts in vitro Am. J. Path. 84 1976 501 514
Limeback H.F. Sodek J. Procollagen synthesis and processing in periodontal ligament in vivo and in vitro . A comparative study using slab-gel fluorography Eur. J. Biochem. 100 1979 541 550
Limeback H.F. Sodek J. Brunette D.M. Nature of collagens synthesized by monkey periodontal-ligament fibroblasts in vitro Biochem. J. 170 1978 63 71
Liotta L.A. Abe S. Robey P.G. Martin G.R. Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor Proc. Natl. Acad. Sci. USA 76 1979 2268 2272
Liotta L.A. Lanzer W.L. Garbisa S. Identification of a type V collagenolytic enzyme Biochem. Biophys. Res. Comm. 98 1981 184 190
Little C.D. Church R.L. Miller R.A. Ruddle F.H. Procollagen and collagen produced by a teratocarcinoma-derived cell line, TSD4: Evidence for a new molecular form of collagen Cell 10 1977 287 295
Löning Th. Albers H.-H. Lisboa B.P. Burkhardt A. Caselitz J. Prostaglandin E and the local immune response in chronic periodontal disease. Immunohistochemical and radioimmunological observations J. Periodont. Res. 15 1980 525 535
Mainardi C.L. Hasty D.L. Seyer J.M. Kang A.H. Specific cleavage of human type III collagen by human polymorphonuclear leukocyte elastase J. Biol. Chem. 255 1980 12006 12010
Martin G.M. Sprague C.A. Norwood T.H. Pendergrass W.R. Clonal selection, attenuation and differentiation in an in vitro model of hyperplasia Am. J. Path. 74 1974 137 153
Mayne R. Vail M.S. Mayne P.M. Miller E.J. Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity Proc. Natl. Acad. Sci. USA 73 1976 1674 1678
Mayne R. Vail M.S. Miller E.J. Analysis of changes in collagen biosynthesis that occur when chick chondrocytes are grown in 5-bromo-2-deoxyuridine Proc. Natl. Acad. Sci. USA 72 1975 4511 4515
Mayne R. Vail M.S. Miller E.J. The effect of embryo extract on the types of collagen synthesized by cultured chick chondrocytes Dev. Biol. 54 1976 230 240
Mayne R. Vail M.S. Miller E.J. Characterization of collagen chains synthesized by cultured smooth muscle cells derived from rhesus monkey thoracic aorta Biochemistry 17 1978 446 452
Miller E.J. Finch J.E. Jr. Chung E. Butler W.T. Specific cleavage of the native type III collagen molecule with trypsin. Similarity of the cleavage products to collagenase-produced fragments and primary str Arch. Biochem. Biophys. 173 1976 631 637
Milunsky A. Spielvogel C. Kanfer J.N. Lysosomal enzyme variations in cultured normal skin fibroblast Life Sciences 11 1972 1101 1107
Moro L. Smith B.D. Identification of collagen α1(I) trimer and normal type I collagen in a polyoma virus-induced mouse tumor Arch. Biochem. Biophys. 182 1977 33 41
Munksgaard E.C. Rhodes M. Mayne R. Butler W.T. Collagen synthesis and secretion by rat incisor odontoblasts in organ culture Eur. J. Biochem. 82 1978 609 617
Narayanan, A.S., Engel, L. D., and Page, R.C.: Collagen α-A and α-B chain content is elevated in inflamed gingiva. J. Dent. Res. 60, Special Issue A : 337, 1981 a.
Narayanan A.S. Hassell T.M. Page R.C. Hoke J.A. Meyers D. Human edentulous ridge collagens. Characterization and comparison with gingival collagens J. Periodont. Res. 16 1981 b 504 512
Narayanan A.S. Page R.C. Biochemical characterization of collagens synthesized by fibroblasts derived from normal and diseased human gingiva J. Biol. Chem. 251 1976 5464 5471
Narayanan A.S. Page R.C. Serum modulates collagen types in human gingiva fibroblasts FEBS Lett. 80 1977 221 224
Narayanan A.S. Page R.C. Kuzan F. Collagens synthesized in vitro by diploid fibroblasts obtained from chronically inflamed human connective tissues Lab. Invest. 39 1978 61 65
Narayanan A.S. Page R.C. Meyers D.F. Characterization of diseased human gingiva Biochemistry 19 1980 5037 5043
Narayanan A.S. Page R.C. Meyers D.F. Cellular origin of type V collagen in human gingiva J. Dent. Res. 61 1982 315
Nielson E.G. Jimenez S.A. Phillips S.M. Cell-mediated immunity in interstitial nephritis. III. T lymphocyte-mediated fibroblast proliferation and collagen synthesis: An immune mechanism for renal fi J. Immunol. 125 1980 1708 1714
Nimni M. Deshmukh K. Differences in collagen metabolism between normal and osteoarthritic human articular cartilage Science 181 1973 751 752
Nuki K. Soskolne W.A. Raisz L.G. Kornman K.S. Alander C. Bone resorbing activity of gingiva from beagle dogs following metronidazole and indomethacin therapy J. Periodont. Res. 16 1981 205 212
In Page R.C. Macromolecular Interactions in the Connective Tissues of the Periodontium ed. by H. Slavkin L. Bavetta Developmental Aspects of Oral Biology 1972 Academic Press New York 291 308
Page R.C. Ammons W.F. Collagen turnover in the gingiva and other mature connective tissues of the marmoset Saguinus oedipus Arch. Oral Biol. 19 1974 651 659
Paeg R.C. Davies P. Allison A.C. Effects of dental plaque on the production and release of lysosomal hydrolases by macrophages in culture Arch. Oral Biol. 18 1973 1481 1495
Page R.C. Davies P. Allison A.C. The role of the mononuclear phagocyte in chronic inflammatory disease J. Reticuloendothel. Soc. 15 1974 413 438
Page R.C. Davies P. Allison A.C. The macrophage as a secretory cell Int. Rev. Cytol. 52 1978 119 157
Page R.C. Engel L.D. Narayanan A.S. Clagett J.A. Chronic inflammatory gingival and periodontal disease J. Am. Med. Assoc. 240 1978 545 550
Page, R.C., Narayanan, A.S., Lindhe, J., and Clagett, J.A.: Acid soluble proteins of normal, regenerated and periodontally diseased gingiva. J. Periodont. Res. , submitted.
Page R.C. Narayanan A.S. Schroeder H.C. Connective tissue composition and collagen synthesis in diseased and normal gingiva of adult dogs with spontaneous periodontitis Arch. Oral Biol. 25 1980 727 736
Page R.C. Schroeder H.E. Biochemical aspects of connective tissue alterations in inflammatory gingival and periodontal disease Int. Dent. J. 23 1973 455 469
Page R.C. Schroeder H.E. Pathogenesis of chronic inflammatory periodontal disease: A summary of current work Lab. Invest. 33 1976 235 249
Page R.C. Schroeder H.E. Periodontitis in Man and Other Animals 1982 S. Karger Publishing Co. New York
Page R.C. Simpson D.M. Ammons W.F. Host tissue response in chronic inflammatory periodontal disease. IV. The periodontal and dental status of a group of aged great apes J. Periodontal. 46 1975 144 155
Pantalone R. Page R.C. Enzyme production and secretion by lymphokine-activated macrophages J. Reticuloendothel. Soc. 21 1977 343 357
Payne W.A. Page R.C. Ogilvie A.L. Hall W.G. Histopathologic features of the initial and early stages of experimental gingivitis in man J. Periodont. Res. 10 1975 51 645
Pinsky L. Finkelberg R. Straisfeld C. Zilahi B. Kaufman M. Hall G. Testosterone metabolism by serially subcultured fibroblasts from genital and nongenital skin of individual human donors Biochem. Biopbys. Res. Comm. 46 1972 364 368
Ross R. Vogel A. The platelet-derived growth factor Cell 14 1978 203 210
Sage H. Bornstein P. Characterization of a novel collagen chain in human placenta and its relation to AB collagen Biochemistry 18 1979 3815 3822
Sage H. Pritzl P. Bornstein P. Susceptibility of type V collagen to neutral proteases: Evidence that the major molecular species is a thrombin sensitive heteropolymer α1(V)2 α2(V) Biochemistry 20 1981 3778 3784
Scher C.D. Shepard R.E. Antoniades H.N. Stiles C.D. Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle Biochem. Biopbys. Acta 560 1979 217 241
Schneir M. Ogata S. Fine A. Confirmation that neither phenotype nor hydroxylation of collagen is altered in overgrown gingiva from dip henylhydantoin-treated patients J. Dent. Res. 57 1978 506 510
Schneir M. Vogan I. Yu H. Yavelow J. Liu-Montcalm A. Furuto D. Ability of salt and acetic acid to extract human and animal gingival collagen J. Dent. Res. 54 1975 1095
Schroeder H.E. Münzel-Pedrazzoli S. Page R.C. Correlated morphometric and biochemical analysis of early chronic gingivitis in man Arch. Oral Biol. 18 1973 899 923
Schroeder H.E. Page R.C. Lymphocyte-fibroblast interactions in the pathogenesis of inflammatory gingival disease Experientia 28 1972 1228 1229
Schultz-Haudt S.D. Aas E. Observations on the status of collagen in human gingiva Arch. Oral Biol. 2 1960 131 142
Schultz-Haudt S.D. From S.H. Nordbo H. Histochemical staining properties of isolated polysaccharide components of human gingiva Arch. Oral Biol. 9 1964 17 25
Seppa H. Grotendorst G. Seppa S. Schiffman E. Martin G.R. Platelet-derived growth factor is chemotactic for fibroblasts J. Cell Biol. 92 1982 584 588
Seyer J.M. Hutcheson E.T. Kang A.H. Collagen polymorphism in idiopathic chronic pulmonary fibrosis J. Clin. Inv. 57 1976 1498 1507
Seyer J.M. Hutcheson E.T. Kang A.H. Collagen polymorphism in normal and cirrhotic human liver J.Clin. Invest. 59 1977 241 248
Smith J.R. Hayflick L. Variation in the lifespan of clones derived from human diploid cell strains J. Cell Biol. 62 1974 48 53
Soames J.V. Davies R.M. Intracellular collagen fibrils in early gingivitis in the beagle dog J. Periodont. Res. 12 1977 378 386
Sodek J. A new approach to assessing collagen turnover by using a micro-assay. A highly efficient and rapid turnover of collagen in rat periodontal tissues Biochem. J. 160 1976 243 246
Sodek J. Limeback H.F. Comparison of the rates of synthesis, conversion, and maturation of type I and type III collagens in rat periodontal tissues J. Biol. Chem. 254 1979 10496 10502
Soskolne W.A. Nuki K. Raisz G. Alander C. The appearance of bone resorbing activity in ligature induced gingivitis in dogs J. Periodont. Res. 15 1980 373 379
Stern B.D. Collagen solubility of normal and inflamed. human gingivae Periodontics 5 1967 167 171
Staple P.H. Reed M.J. Diphenylhydantoin gingival hyperplasia: Prevention by inhibition of dental plaque deposition J. Dent. Res. 55 1976 799
Taichman N.S. McArthur W.P. Interaction of inflammatory cells and oral bacteria: Release of lysosomal hydrolases from rabbit polymorphonuclear leukocytes exposed to gram-positive plaque Arch. Oral Biol. 21 1976 257 263
Taichman N.S. Tsai C.-C. Baehni P.C. Stoller N. McArthur W.P. Interaction of inflammatory cells and oral microorganisms. IV. In vitro release of lysosomal constituents from polymorphonuclear leukocytes exposed to sup Infect. Immunity 16 1977 1013 1023
Ten Cate A.R. Deporter D.A. The degradative role of the fibroblast in the remodeling and turnover of collagen in soft connective tissue Anat. Rec. 182 1975 1 14
Thonard J.C. Scherp H.W. Histochemical demonstration of acid mucopolysaccharides in human gingival epithelial intercellular spaces Arch. Oral Biol. 7 1962 125 136
Uitto J. Collagen polymorphism: Isolation and partial characterization of a1(I) trimer molecules in normal human skin Arch. Biochem. Biophys. 192 1979 371 379
Wahl L.M. Olsen C.E. Sandberg A.L. Mergenhagen S.E. Prostaglandin regulation of macrophage collagenase production Proc. Natl. Acad. Sci. USA 74 1977 495S 4958
Wahl L.M. Wahl S.M. Mergenhagen S.E. Martin G.R. Collagenase production by lymphokine-activated macrophages Science 187 1975 167 263
Wahl S.M. Wahl L.M. McCarthy J.B. Lymphocyte-mediated activation of fibroblast proliferation and collagen production J. Immunol. 121 1978 942 946
Walker S.M. Lucas Z.J. Cytotoxic activity of lymphocytes. II. Studies on mechanism of lymphotoxin —mediated cytoto-xicity J. Immunol. 109 1972 1233 1244
Wiebkin O.W. Bartold P.M. Thonard J.C. Proteoglycans from adult human gingival epithelium Biochem. J. 183 1979 467 470
