Article (Scientific journals)
Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.
MacDonald, Thomas M; Reginster, Jean-Yves; Littlejohn, Thomas W et al.
2008In Journal of Hypertension, 26 (8), p. 1695-702
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Keywords :
Aged; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/adverse effects; Blood Pressure/drug effects; Blood Pressure Monitoring, Ambulatory; Cyclooxygenase 2 Inhibitors/administration & dosage/adverse effects; Diclofenac/administration & dosage/adverse effects/analogs & derivatives; Humans; Hypertension/complications/drug therapy; Ibuprofen/administration & dosage/adverse effects; Middle Aged; Osteoarthritis/complications/drug therapy; Treatment Outcome
Abstract :
[en] OBJECTIVES: Nonsteroidal anti-inflammatory drugs vary in their impact on blood pressure and the effect of lumiracoxib 100 mg once daily has not been studied previously. To examine whether lumiracoxib 100 mg once daily would result in lower 24-h mean systolic ambulatory blood pressure than ibuprofen 600 mg three times daily in osteoarthritis patients with controlled hypertension, a 4-week, randomized, double-blind, parallel-group study was conducted in 79 centres in nine countries. METHODS: Hypertensive osteoarthritis patients of 50 years at least whose office blood pressure was less than 140/90 mmHg on stable antihypertensive treatment were randomized to lumiracoxib (n = 394) 100 mg once daily or ibuprofen 600 mg three times daily (n = 393) and 24-h ambulatory blood pressure monitoring was performed at baseline and end of study. The primary outcome measure was a comparison of the change in 24-h mean systolic ambulatory blood pressure from baseline to week 4. Secondary analyses included other blood pressure-related endpoints and efficacy (pain) measurements. RESULTS: Compared with baseline, the 24-h mean systolic ambulatory blood pressure (least square mean) decreased in lumiracoxib-treated patients (-2.7 mmHg) and increased in ibuprofen-treated patients (+2.2 mmHg) at 4 weeks, estimated difference -5.0 mmHg (95% confidence interval -6.1 to -3.8) in favour of lumiracoxib. The 24-h mean diastolic ambulatory blood pressure changes were -1.5 mmHg (lumiracoxib), +0.5 mmHg (ibuprofen), difference -2.0 mmHg (95% confidence interval -2.7 to -1.3). Efficacy results were comparable. CONCLUSIONS: Treatment with lumiracoxib 100 mg once daily resulted in clinically significant lower blood pressure compared with ibuprofen 600 mg three times daily in osteoarthritis patients with well controlled hypertension.
Disciplines :
General & internal medicine
Author, co-author :
MacDonald, Thomas M
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Littlejohn, Thomas W
Richard, Dominik
Lheritier, Karine
Krammer, Gerhard
Rebuli, Rosemary
Language :
English
Title :
Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.
Publication date :
2008
Journal title :
Journal of Hypertension
ISSN :
0263-6352
eISSN :
1473-5598
Publisher :
Lippincott Williams & Wilkins, London, United Kingdom
Volume :
26
Issue :
8
Pages :
1695-702
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 February 2011

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