ORBi: Manette Christine - Comprehensive therapy in osteoporosis using a single drug: From ADFR to strontium ranelate

Reference : Comprehensive therapy in osteoporosis using a single drug: From ADFR to strontium ranelate


	Document type :	Scientific journals : Article
	Discipline(s) :	Human health sciences : Pharmacy, pharmacology & toxicology Physical, chemical, mathematical & earth Sciences : Chemistry Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/83685

Title :	Comprehensive therapy in osteoporosis using a single drug: From ADFR to strontium ranelate
Language :	English
Author, co-author :	Manette, Christine [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique >]
	Collette, Julien [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
	Sarlet, Nathalie [Centre Hospitalier Universitaire de Liège - CHU > > Médecine de l'appareil locomoteur >]
	Tancredi, Annalisa [Université de Liège - ULg > Département des sciences de la santé publique > Ecole de santé publique >]
	Zegels, Brigitte [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique]
	Reginster, Jean-Yves [Université de Liège - ULg > Département des sciences de la santé publique > Epidémiologie et santé publique >]
Publication date :	2006
Journal title :	Current Medicinal Chemistry
Publisher :	Bentham Science Publ Ltd
Volume :	13
Issue/season :	13
Pages :	1585-1590
Audience :	International
ISSN :	0929-8673
City :	Sharjah
Keywords :	[en] osteoporosis ; treatment ; fractures ; strontium ranelate
Abstract :	[en] In vitro, strontium ranelate increases collagen and non-collagenic proteins synthesis by mature osteoblast enriched cells. The effects of strontium ranelate on bone formation were confirmed as the drug enhanced preosteoblastic cell replication. In the isolated rat osteoclast, a preincubation of bone slices with strontium ranclate induced a dose-dependent inhibition of the bone resorbing activity of treated rat osteoclast. Strontium ranelate dose-dependently inhibited preosteoclast differentiation. In a phase 11 dose ranging trial Strontium ranclate (500 mg. 1000 mg, 2000 mg/day) or placebo were given to 353 postmenopausal women with prevalent vertebral osteoporosis. At the conclusion of this 2-year study. the annual increase in lumbar BMD of the group receiving 2000 mg of strontium ranclate was + 7.3%. a significant increase in bone alkaline phosphatase, over a 6-month period and a significant decrease in N-telopeptide crosslinks throughout the 2-year period were seen. During the second year of treatment, the dose of 2000 mg was associated with a 44% reduction in the number of patients experiencing a new vertebral deformity. The primary analysis of the SOTI study, evaluatine the effect of strontium ranelate 2000 mg on vertebral fracture rates, revealed a 41% reduction in the relative risk of patient experiencing a first new vertebral fracture with strontium ranelate throughout the 3-year study. The TROPOS study showed a significant reduction in the risk of experiencing a first non-vertebral fracture by 16% in the group treated with strontium ranclate throughout the 3-year study. A reduction in the risk of experiencing a hip fracture by 36% was also demonstrated in the patients at high risk of hip fracture (age >= 74 years and Femoral Neck T score <=-2.4 according to NHANES normative value).
Permalink :	http://hdl.handle.net/2268/83685

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