Reference : DD-carboxypeptidase-transpeptidase and killing site of β-lactam antibiotics in Strept...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Microbiology
http://hdl.handle.net/2268/83536
DD-carboxypeptidase-transpeptidase and killing site of β-lactam antibiotics in Streptomyces strains R39, R61, and K11
English
Dusart, Jean [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Marquet, Alberto [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Ghuysen, Jean-Marie [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Frère, Jean-Marie mailto [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > >]
Moreno, Ramon [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Leyh-Bouille, Mélina [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Johnson, Kenneth [National Research Council of Canada (Ottawa) > Division of Biological Sciences > > > >]
Lucchi, Chantal [> > > > >]
Perkins, Harnold R. [National Institute for Medical Research > > > > >]
Nieto, Manuel [Instituto de Biologia Celular > Centro de Investigaciones Biologicas > > > >]
2-Feb-1973
Antimicrobial Agents and Chemotherapy
American Society for Microbiology (ASM)
3
2
181-187
Yes (verified by ORBi)
International
0066-4804
1098-6596
Washington
DC
[en] acyltransferases metabolism ; anti-bacterial agents ; carboxypeptidases ; penicillinase metabolism ; streptomyces/ ; beta-lactams ; pharmacology ; antagonists & inhibitors ; metabolism ; drug effects
[en] Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs dd-carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of beta-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity towards some antibiotics different from that of the membrane-bound enzyme. Under the growth conditions used in the present investigations, beta-lactamase activity was not involved in susceptibility to beta-lactam antibiotics.
Fonds de la Recherche Fondamentale Collective
Researchers ; Professionals
http://hdl.handle.net/2268/83536

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