ORBi: Dusart Jean - DD-carboxypeptidase-transpeptidase and killing site of beta-lactam antibiotics in Streptomyces strains R39, R61, and K11

Reference : DD-carboxypeptidase-transpeptidase and killing site of beta-lactam antibiotics in Strept...


	Document type :	Scientific journals : Article
	Discipline(s) :	Life sciences : Microbiology Life sciences : Biochemistry, biophysics & molecular biology
	To cite this reference:	http://hdl.handle.net/2268/83536

Title :	DD-carboxypeptidase-transpeptidase and killing site of beta-lactam antibiotics in Streptomyces strains R39, R61, and K11
Language :	English
Author, co-author :	Dusart, Jean [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
	Marquet, Alberto [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
	Ghuysen, Jean-Marie [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
	Frère, Jean-Marie [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > >]
	Moreno, Ramon [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
	Leyh-Bouille, Mélina [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
	Johnson, Kenneth [National Research Council of Canada (Ottawa) > Division of Biological Sciences > > > >]
	Lucchi, Chantal [> > > > >]
	Perkins, Harnold R. [National Institute for Medical Research > > > > >]
	Nieto, Manuel [Instituto de Biologia Celular > Centro de Investigaciones Biologicas > > > >]
Publication date :	2-Feb-1973
Journal title :	Antimicrobial Agents and Chemotherapy
Publisher :	American Society for Microbiology (ASM)
Volume :	3
Issue/season :	2
Pages :	181-187
Audience :	International
ISSN :	0066-4804
e-ISSN :	1098-6596
City :	Washington
Country :	DC
Keywords :	[en] acyltransferases metabolism ; anti-bacterial agents ; carboxypeptidases ; penicillinase metabolism ; streptomyces/ ; beta-lactams ; pharmacology ; antagonists & inhibitors ; metabolism ; drug effects
Abstract :	[en] Additional evidence is given that in Streptomyces strains R39, R61, and K11 the same enzyme performs dd-carboxypeptidase and transpeptidase activities and that this enzyme is the killing site of beta-lactam antibiotics. With strain R61, it was found that the exocellular enzyme has a sensitivity towards some antibiotics different from that of the membrane-bound enzyme. Under the growth conditions used in the present investigations, beta-lactamase activity was not involved in susceptibility to beta-lactam antibiotics.
Funders :	Fonds de la Recherche Fondamentale Collective
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/83536

File(s) associated to this reference

Fulltext file(s):

	File	Commentary	Version	Size	Access
Open access	DUSART_1973_dd.pdf		Publisher postprint	2.89 MB	View/Open

All documents in ORBi are protected by a user license.

Dspace v1.5