Article (Scientific journals)
Laminin--a glycoprotein from basement membranes.
Timpl, R.; Rhode, H.; Robey, P. G. et al.
1979In Journal of Biological Chemistry, 254 (19), p. 9933-7
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Abstract :
[en] We have isolated a large noncollagenous glycoprotein, laminin, from a mouse tumor that produces basement membrane. The protein consists of at least two polypeptide chains (Mr = 220,000 and Mr = 440,000) joined to each other by disulfide bonds. Laminin and type IV collagen are major constituents of the tumor. Laminin is distinctly different from fibronectin, another component of basement membranes, in amino acid composition and immunological reactivity. Pepsin digestion of laminin releases a large, cystine-rich fragment which retains most of the antigenicity of the original protein. Immunological studies using purified antibody against laminin show that it is produced by a variety of cultured cells. In addition, these antibodies react with the basement membranes of normal tissues, suggesting that this protein or an immunologically related protein is a constituent of the basement membranes of these tissues.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Timpl, R.
Rhode, H.
Robey, P. G.
Rennard, S. I.
Foidart, Jean-Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement
Martin, G. R.
Language :
English
Title :
Laminin--a glycoprotein from basement membranes.
Publication date :
1979
Journal title :
Journal of Biological Chemistry
ISSN :
0021-9258
eISSN :
1083-351X
Publisher :
American Society for Biochemistry and Molecular Biology, Baltimore, United States - Maryland
Volume :
254
Issue :
19
Pages :
9933-7
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 February 2011

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