Reference : The penicillin receptor in Streptomyces
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Life sciences : Microbiology
http://hdl.handle.net/2268/83092
The penicillin receptor in Streptomyces
English
Ghuysen, Jean-Marie [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Leyh-Bouille, M. [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Frère, Jean-Marie mailto [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > >]
Dusart, Jean [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Marquet, Andrée mailto [Université de Liège - ULg > Faculté de Médecine, Institut de Botanique > Service de Microbiologie > > >]
Perkins, Harnold R. [National Institute for Medical Research > > > > >]
Nieto, Manuel [National Institute for Medical Research > > > >]
10-May-1974
Annals of the New York Academy of Sciences
New York Academy of Sciences
235
236-268
Yes (verified by ORBi)
International
0077-8923
New York
NY
[en] acyltransferases/metabolism ; amides/metabolism ; carbon radioisotopes ; carboxypeptidases/metabolism ; cell membrane/enzymology ; cell wall/enzymology ; cephalosporins/pharmacology ; hydrolysis ; kinetics ; molecular conformation ; penicillin G/pharmacology ; penicillinase/metabolism ; penicillins/*metabolism/pharmacology ; peptide chain termination, translational ; peptide elongation factors ; peptides/metabolism ; receptors, drug ; streptomyces/cytology/*enzymology
[en] Kinetics and optical studies of Streptomyces DD-carboxypeptidases-transpeptidases led to the conclusion that the donor, acceptor, and penicillin sites on these enzymes are different but not independent and that penicillin acts as a modifier of the conformation of the protein. In the presence of penicillin, the penicillin-sensitive enzymes would be frozen in a conformation that prevents catalytic activity.
Fonds de la Recherche Fondamentale Collective
Researchers ; Professionals
http://hdl.handle.net/2268/83092
also: http://hdl.handle.net/2268/58028
10.1111/j.1749-6632.1974.tb43269.x

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