Reference : Penicillin-binding proteins and carboxypeptidase/transpeptidase activities in Proteus vu...
Scientific journals : Article
Life sciences : Microbiology
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/83020
Penicillin-binding proteins and carboxypeptidase/transpeptidase activities in Proteus vulgaris P18 and its penicillin-induced stable L-forms
English
Rousset, André [Université de Strasbourg > Faculté de Medecine > Institut de Bactériologie > >]
Nguyen-Distèche, Martine mailto [Université de Liège - ULg > Faculté de Médecine, Institut de Chimie > Service de Microbiologie appliquée aux sciences pharmaceutiques > >]
Minck, Raymond [Université de Strasbourg > Faculté de Medecine > Institut de Bactériologie > >]
Ghuysen, Jean-Marie [Université de Liège - ULg > aculté de Médecine, Institut de Chimie > Service de Microbiologie > > >]
1-Dec-1982
Journal of Bacteriology
American Society for Microbiology (ASM)
152
3
1042-1048
Yes (verified by ORBi)
International
0021-9193
1098-5530
Washington
DC
[en] bacterial proteins ; carboxypeptidases metabolism ; carrier proteins analysis metabolism ; cell membrane ; hexosyltransferases ; l forms ; muramoylpentapeptide carboxypeptidase/*metabolism ; penicillin-binding proteins ; penicillins pharmacology ; peptidyl transferases ; proteus vulgaris/analysis/*metabolism
[en] The originally penicillin-induced, wall-less stable L-forms of Proteus vulgaris P18, isolated by Tulasne in 1949 and since then cultured in he absence of penicillin, have kept the ability to synthesize the seven penicillin-binding proteins and the various DD- and LD-peptidase activities found in the parental bacteria and known to be involved in wall peptidoglycan metabolism. The stable L-forms, however, secrete during growth both the highly penicillin-sensitive, DD-carboxy-peptidase-transpeptidase penicillin-binding protein PBP4 (which in normal bacteria is relatively loosely bound to the plasma membrane) and the penicillin-insensitive LD-carboxypeptidase (which in normal bacteria is located in the periplasmic region).
Fonds de la Recherche Scientifique Médicale - FRSM ; National Institutes of Health - NIH
Researchers ; Professionals
http://hdl.handle.net/2268/83020

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