Reference : [18F]fallypride binding in the mouse brain: test-retest and effects of registration
Scientific congresses and symposiums : Unpublished conference
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/82728
[18F]fallypride binding in the mouse brain: test-retest and effects of registration
English
Bahri, Mohamed Ali mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Geuzaine, Annabelle mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Warnock, Geoffrey [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Goblet, David mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Tirelli, Ezio mailto [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
Lemaire, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Seret, Alain mailto [Université de Liège - ULg > Département de physique > Imagerie médicale expérimentale >]
Salmon, Eric mailto [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Plenevaux, Alain mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
17-Jan-2011
1
Yes
International
Hot Topics in Molecular Imaging 2011 (TOPIM 2011) - The 5th Winter Conference of the European Society for Molecular Imaging
January 16-21, 2011
European Society for Molecular Imaging
Les Houches
France
[en] Fallypride ; Brain ; Mouse ; PET ; Test-retest ; Registration
[en] The quantification of in vivo receptor kinetics with PET tracer experiments is an intricate and challenging problem especially for small animals such as rats and mice. A test-retest scan is usually set up in order to confirm an observed experimental effect or to examine the reliability of the experiment design. Inadequate processing of the image data may also mask small effects. The purpose of this study was to investigate the effect of image registration on [18F]fallypride binding potentials calculated from PET mouse test-retest data. Sub-optimal registration affected the quantification of in vivo receptor kinetics with [18F]fallypride. The absence of anatomical information in the [18F]fallypride image and the lack of a homogeneous tracer distribution, even during the earlier minutes of the scan, lead to erroneous automatic registration. A FDG scan after each [18F]fallypride test could improve registration as FDG provides a more homogeneous brain image. Variability in the data could also result from stress induced by anaesthesia or the experimental environment.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/82728

There is no file associated with this reference.

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.