ORBi: Bahri Mohamed Ali - [18F]fallypride binding in the mouse brain: test-retest and effects of registration

Reference : [18F]fallypride binding in the mouse brain: test-retest and effects of registration


	Document type :	Scientific congresses and symposiums : Unpublished conference
	Discipline(s) :	Human health sciences : Radiology, nuclear medicine & imaging
	To cite this reference:	http://hdl.handle.net/2268/82728

Title :	[18F]fallypride binding in the mouse brain: test-retest and effects of registration
Language :	English
Author, co-author :	Bahri, Mohamed Ali [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Geuzaine, Annabelle [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
	Warnock, Geoffrey [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Goblet, David [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Tirelli, Ezio [Université de Liège - ULg > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
	Lemaire, Christian [Université de Liège - ULg > > Centre de recherches du cyclotron >]
	Seret, Alain [Université de Liège - ULg > Département de physique > Imagerie médicale expérimentale >]
	Salmon, Eric [Université de Liège - ULg > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
	Luxen, André [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
	Plenevaux, Alain [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Publication date :	17-Jan-2011
Page number :	1
Peer reviewed :	Yes
Audience :	International
Event name :	Hot Topics in Molecular Imaging 2011 (TOPIM 2011) - The 5th Winter Conference of the European Society for Molecular Imaging
Event date :	January 16-21, 2011
Event organizer :	European Society for Molecular Imaging
Event place (city) :	Les Houches
Event country :	France
Keywords :	[en] Fallypride ; Brain ; Mouse ; PET ; Test-retest ; Registration
Abstract :	[en] The quantification of in vivo receptor kinetics with PET tracer experiments is an intricate and challenging problem especially for small animals such as rats and mice. A test-retest scan is usually set up in order to confirm an observed experimental effect or to examine the reliability of the experiment design. Inadequate processing of the image data may also mask small effects. The purpose of this study was to investigate the effect of image registration on [18F]fallypride binding potentials calculated from PET mouse test-retest data. Sub-optimal registration affected the quantification of in vivo receptor kinetics with [18F]fallypride. The absence of anatomical information in the [18F]fallypride image and the lack of a homogeneous tracer distribution, even during the earlier minutes of the scan, lead to erroneous automatic registration. A FDG scan after each [18F]fallypride test could improve registration as FDG provides a more homogeneous brain image. Variability in the data could also result from stress induced by anaesthesia or the experimental environment.
Funders :	Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Target :	Researchers ; Professionals
Permalink :	http://hdl.handle.net/2268/82728

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