Dioxin; Municipal solid waste incinerator; Non-Hodgkin lymphoma; Organochlorines; Polychlorinated biphenyls
Abstract :
[en] Organochlorine chemicals may contribute to an increased risk of non-Hodgkin lymphoma (NHL) within nonoccupationally
exposed populations. Among these chemicals, dioxins and furans were mainly released by
municipal solid waste incinerators (MSWIs) until a recent past in France, a source of exposure that is of public
concern. We investigated organochlorines and the risk of NHL among neighbors of a French MSWI with high
levels of dioxin emissions (Besançon, France), using serum concentrations to assess exposure. The study area
consisted of three electoral wards, containing or surrounding the MSWI. Pesticides, dioxins, furans, and
polychlorinated biphenyls (PCBs) were measured in the serum of 34 newly diagnosed NHL cases (2003–
2005) and 34 controls. Risks of NHL associated with each lipid-corrected serum concentration were estimated
using exact logistic regression. The pesticides β-hexachlorocyclohexane (odds ratio [OR]=1.05, 95%
confidence interval [CI]=1.00–1.12, per 10 ng/g lipid) and p,p' dichloro-diphenyl-trichloroethane (DDT)
(OR=1.20, 95% CI=1.01-1.45, per 10 ng/g lipid) were associated with NHL risk. Evidence indicated an
increased NHL risk associated with cumulative WHO1998-toxic equivalency factor (TEQ) concentrations
(dioxins, OR=1.12, 95% CI=1.03–1.26; furans, OR=1.16, 95% CI=1.03–1.35; dioxin-like PCBs, OR=1.04,
95% CI=1.00–1.07; and total TEQ, OR=1.04, 95% CI=1.01–1.05), as well as with non dioxin-like PCBs
(OR=1.02, 95% CI=1.01–1.05, per 10 ng/g lipid). Most congener-specific associations were statistically
significant. This study provides strong and consistent support for an association between serum cumulative
WHO1998-TEQ concentrations, at levels experienced by people residing in the vicinity of a polluting MSWI, and
risk of NHL.
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Chemistry Public health, health care sciences & services
Author, co-author :
Viel, Jean-François
Floret, Nathalie
Deconinck, Eric
Focant, Jean-François ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique, organique et biologique
De Pauw, Edwin ; Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Cahn, Jean-Yves
Language :
English
Title :
Increased risk of non-Hodgkin lymphoma and serum organochlorine concentrations among neighbors of a municipal solid waste incinerator
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