Reference : Effects of betamethasone on inflammation and emphysema induced by cadmium nebulisation i...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/8234
Effects of betamethasone on inflammation and emphysema induced by cadmium nebulisation in rats
English
Fievez, Laurence mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Kirschvink, N. [ > > ]
Zhang, Wenhui H. [ > > ]
Lagente, Vincent [ > > ]
Lekeux, Pierre mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire >]
Bureau, Fabrice mailto [Université de Liège - ULg > Département de sciences fonctionnelles > GIGA-R : Biochimie et biologie moléculaire >]
Gustin, Pascal mailto [Université de Liège - ULg > Département de sciences fonctionnelles > Pharmacologie, pharmacothérapie et toxicologie >]
2009
European Journal of Pharmacology
Elsevier Science
606
1-3
210-214
Yes (verified by ORBi)
International
0014-2999
Amsterdam
The Netherlands
[en] Cadmium ; Emphysema ; Glucocorticoid ; Inflammation
[en] Cadmium (Cd) induces centrilobular emphysema and is suspected to contribute to tobacco related lung diseases as chronic obstructive pulmonary disease (COPD). This study aimed to check whether the inflammatory process observed in rats exposed to nebulised Cd is resistant to betamethasone as observed in COPD and to determine the influence of this drug on airspace enlargement together with the MMP-2-9/TIMP-1-2 imbalance. Our results showed that betamethasone induced emphysema by itself in healthy rats. Moreover, pre-treatment of rats with betamethasone could only partially modulate the increase in bronchoalveolar lavage fluid cell counts and the absence of preventive effect of this compound against emphysema development is associated with its inability to rebalance the MMP-2-9/TIMP-1-2 ratio.
Researchers ; Professionals
http://hdl.handle.net/2268/8234

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