Article (Scientific journals)
Management of blood glucose in patients with stroke.
Radermecker, Régis; Scheen, André
2010In Diabetes and Metabolism, 36S3, p. 94-S99
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Keywords :
Stroke; Review; CGMS; Insulin therapy; Hypoglycaemia; Diabetes
Abstract :
[en] Stroke is a leading cause of death worldwide and the most common cause of long-term disability amongst adults, more particularly in patients with diabetes mellitus and arterial hypertension. Increasing evidence suggests that disordered physiological variables following acute ischaemic stroke, especially hyperglycaemia, adversely affect outcomes. Post-stroke hyperglycaemia is common (up to 50% of patients) and may be rather prolonged, regardless of diabetes status. A substantial body of evidence has demonstrated that hyperglycaemia has a deleterious effect upon clinical and morphological stroke outcomes. Therefore, hyperglycaemia represents an attractive physiological target for acute stroke therapies. However, whether intensive glycaemic manipulation positively influences the fate of ischaemic tissue remains unknown. One major adverse event of management of hyperglycaemia with insulin (either glucose-potassium-insulin infusions or intensive insulin therapy) is the occurrence of hypoglycaemia, which can also induce cerebral damage. Novel insights into post-stroke hyperglycaemia management have been derived from continuous glucose monitoring systems (CGMS). This article aims: 1) to describe the adverse effects of hyperglycaemia following acute ischaemic stroke and the risk associated with iatrogenic hypoglycaemia; 2) to summarise the evidence from current glucose-lowering treatment trials; and 3) to show the usefulness of CGMS in both non-diabetic and diabetic patients with acute stroke.
Disciplines :
Cardiovascular & respiratory systems
Endocrinology, metabolism & nutrition
Author, co-author :
Radermecker, Régis ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Language :
English
Title :
Management of blood glucose in patients with stroke.
Publication date :
2010
Journal title :
Diabetes and Metabolism
ISSN :
1262-3636
eISSN :
1878-1780
Publisher :
Masson, Moulineaux Cedex 9, France
Volume :
36S3
Pages :
S94-S99
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright A(c) 2010 Elsevier Masson SAS. All rights reserved.
Available on ORBi :
since 18 January 2011

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