Reference : Nonvisual responses to light exposure in the human brain during the circadian night
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/81890
Nonvisual responses to light exposure in the human brain during the circadian night
English
Perrin, Fabien [Université Claude Bernard Lyon 1 > Neurosciences et Systèmes Sensoriels> >]
Peigneux, Philippe mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Fuchs, Sonia [> > > >]
Verhaeghe, Stéphane [> > > >]
Laureys, Steven mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Middleton, Benita [University of Surrey > Surrey Sleep Research Centre >]
Degueldre, Christian mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Del Fiore, Guy [> > > >]
Vandewalle, Gilles mailto [Université de Liège - ULg > > Centre de recherches du cyclotron >]
Balteau, Evelyne mailto [Université de Liège - ULg > > Centre de recherches du cyclotron - Département de physique >]
Poirrier, Robert mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Moreau, Vincent [> > > >]
Luxen, André mailto [Université de Liège - ULg > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron >]
Maquet, Pierre mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Dijk, Derk Jan [> > > >]
2004
Current Biology
14
20
1842-6
Yes (verified by ORBi)
International
0960-9822
[en] The brain processes light information to visually represent the environment but also to detect changes in ambient light level. The latter information induces non-image-forming responses and exerts powerful effects on physiology such as synchronization of the circadian clock and suppression of melatonin. In rodents, irradiance information is transduced from a discrete subset of photosensitive retinal ganglion cells via the retinohypothalamic tract to various hypothalamic and brainstem regulatory structures including the hypothalamic suprachiasmatic nuclei, the master circadian pacemaker. In humans, light also acutely modulates alertness, but the cerebral correlates of this effect are unknown. We assessed regional cerebral blood flow in 13 subjects attending to auditory and visual stimuli in near darkness following light exposures (>8000 lux) of different durations (0.5, 17, 16.5, and 0 min) during the biological night. The bright broadband polychromatic light suppressed melatonin and enhanced alertness. Functional imaging revealed that a large-scale occipito-parietal attention network, including the right intraparietal sulcus, was more active in proportion to the duration of light exposures preceding the scans. Activity in the hypothalamus decreased in proportion to previous illumination. These findings have important implications for understanding the effects of light on human behavior.
http://hdl.handle.net/2268/81890

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